Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France.
Centre d'Investigation Préventive et Clinique (IPC), Paris, France.
Sci Rep. 2017 Mar 15;7:44604. doi: 10.1038/srep44604.
We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16-89 years at recruitment. The mean follow-up time was 3.4 ± 2.4 years. Subjects with a personal medical history of cancer or cardiovascular disease and death by casualty were excluded from the analysis. A full-mouth clinical examination was performed in order to assess dental plaque, dental calculus and gingival inflammation. The number of teeth and functional masticatory units <5 were recorded. Causes of death were ascertained from death certificates. Mortality risk was evaluated using Cox regression model with propensity score calibrated for each oral exposure. All-cause mortality risk were raised with dental plaque, gingival inflammation, >10 missing teeth and functional masticatory units <5. All-cancer mortality was positively associated with dental plaque and gingival inflammation. Non-cardiovascular and non-cancer mortality were also positively associated with high dental plaque (HR = 3.30, [95% CI: 1.76-6.17]), high gingival inflammation (HR = 2.86, [95% CI: 1.71-4.79]), >10 missing teeth (HR = 2.31, [95% CI: 1.40-3.82]) and functional masticatory units <5 (HR = 2.40 [95% CI 1.55-3.73]). Moreover, when ≥3 oral diseases were cumulated in the model, the risk increased for all-cause mortality (HR = 3.39, [95% CI: 2.51-5.42]), all-cancer mortality (HR = 3.59, [95% CI: 1.23-10.05]) and non-cardiovascular and non-cancer mortality (HR = 4.71, [95% CI: 1.74-12.7]). The present study indicates a postive linear association between oral health and mortality.
我们评估了口腔健康与死亡率之间的关系。研究人群包括 76188 名年龄在 16-89 岁的受试者。平均随访时间为 3.4±2.4 年。患有癌症或心血管疾病个人病史和因意外事故死亡的受试者被排除在分析之外。进行了全口临床检查，以评估牙菌斑、牙石和牙龈炎症。记录了牙齿数量和功能咀嚼单位<5。死因从死亡证明中确定。使用协方差分析模型评估死亡率风险，并对每个口腔暴露因素进行倾向评分校准。发现牙菌斑、牙龈炎症、>10 颗缺失牙齿和功能咀嚼单位<5 与全因死亡率风险升高相关。牙菌斑和牙龈炎症与全癌症死亡率呈正相关。非心血管和非癌症死亡率也与高牙菌斑（HR=3.30，[95%CI：1.76-6.17]）、高牙龈炎症（HR=2.86，[95%CI：1.71-4.79]）、>10 颗缺失牙齿（HR=2.31，[95%CI：1.40-3.82]）和功能咀嚼单位<5（HR=2.40[95%CI 1.55-3.73]）呈正相关。此外，当模型中累积≥3 种口腔疾病时，全因死亡率（HR=3.39，[95%CI：2.51-5.42]）、全癌症死亡率（HR=3.59，[95%CI：1.23-10.05]）和非心血管和非癌症死亡率（HR=4.71，[95%CI：1.74-12.7]）的风险增加。本研究表明口腔健康与死亡率之间存在正相关关系。
