Shimozu Yuuki, Kimura Yuriko, Esumi Akari, Aoyama Hiroe, Kuroda Teruo, Sakagami Hiroshi, Hatano Tsutomu
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Molecules. 2017 Mar 15;22(3):470. doi: 10.3390/molecules22030470.
We isolated a new ellagitannin, davicratinic acid A (), together with four known ellagitannins, davidiin (), granatin A (), pedunculagin (), and 3--galloylgranatin A (), from an aqueous acetone extract of dried leaves. The known ellagitannins were identified based on spectroscopic data. The structure of davicratinic acid A (), a monomeric ellagitannin possessing a unique, skew-boat glucopyranose core, was established based on spectroscopic data. Additionally, we examined the effects of several tannins with good yields from this plant on drug-resistant bacteria and human oral squamous cell carcinomas, and found that davidiin () exhibited the most potent antibacterial and antitumor properties among the tannins examined.
我们从干燥树叶的丙酮水提取物中分离出一种新的鞣花单宁——蛇葡萄素A（），以及四种已知的鞣花单宁：蛇葡萄素（）、石榴皮素A（）、没食子酸鞣花单宁（）和3 - 没食子酰石榴皮素A（）。通过光谱数据鉴定了这些已知的鞣花单宁。蛇葡萄素A（）是一种具有独特扭曲船式葡萄糖吡喃糖核心的单体鞣花单宁，其结构也是基于光谱数据确定的。此外，我们研究了从该植物中高产率提取的几种单宁对耐药细菌和人类口腔鳞状细胞癌的影响，发现蛇葡萄素（）在所检测的单宁中表现出最强的抗菌和抗肿瘤特性。
