Dev Som, Babitt Jodie L
Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hemodial Int. 2017 Jun;21 Suppl 1(Suppl 1):S6-S20. doi: 10.1111/hdi.12542. Epub 2017 Mar 15.
Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for chronic kidney disease patients.
铁是众多基本生物过程所必需的元素，但铁过量具有毒性。慢性肾脏病患者常出现全身铁平衡异常，在许多患者中，铁剂给药是贫血管理的主要手段。本综述概述了铁在生物学中的重要作用、全身和细胞铁稳态的调节、铁稳态失衡如何导致疾病以及对慢性肾脏病患者的影响。
