Quérat Laurence, Chen Enping
Department of Clinical Neurosciences, Department of Anterior Segment Disorders, Glaucoma, Neuro-Ophthalmology and Oculoplastics (Clinic 1), St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Acta Ophthalmol. 2017 Aug;95(5):525-529. doi: 10.1111/aos.13389. Epub 2017 Mar 14.
To evaluate the accuracy of the intraocular pressure (IOP) measured by healthy subjects with icare Home and to observe the IOP fluctuation and pattern of IOP fluctuation in healthy subjects over three consecutive days.
Sixty healthy subjects were recruited to the study. IOP was measured by the subjects themselves and by study staff using icare Home tonometers on visits 1 and 2, as well as by study staff using Goldmann applanation tonometry (GAT). Furthermore, the subjects measured their IOP at home for three consecutive days.
Twenty-three per cent of the study eyes were excluded in the statistical analysis due to dropout or non-compliance to the schedule. Approximately 70% of the icare Home measurements were within 3 mmHg of the GAT measurements. Ten to 16% of the study eyes had IOP peaks outside office hours. Sixty-three per cent of the study eyes had different IOP patterns on consecutive days.
Rebound self-tonometry appears to be accurate and could be used to monitor short- and long-term IOP variations. The difference between IOP patterns on consecutive days raises questions as to the certainty of a single IOP measurement as a measure of treatment effect.
评估健康受试者使用icare Home眼压计测量眼压（IOP）的准确性，并观察健康受试者连续三天的眼压波动情况及眼压波动模式。
招募60名健康受试者参与研究。在第1次和第2次访视时，由受试者本人以及研究人员使用icare Home眼压计测量眼压，同时研究人员使用Goldmann压平眼压计（GAT）测量眼压。此外，受试者连续三天在家中测量眼压。
由于退出研究或未遵守研究计划，23%的研究眼被排除在统计分析之外。icare Home测量值约70%与GAT测量值相差在3 mmHg以内。10%至16%的研究眼在办公时间以外出现眼压峰值。63%的研究眼连续几天的眼压模式不同。
回弹式自我眼压测量似乎是准确的，可用于监测短期和长期眼压变化。连续几天眼压模式的差异引发了关于单次眼压测量作为治疗效果衡量指标确定性的疑问。
