Marchand A, Buisson C, Martin L, Martin J-A, Molina A, Ressiot D
Analysis Department, Agence Française de Lutte contre le Dopage (AFLD), 143 avenue Roger Salengro, 92290, Châtenay-Malabry, France.
Control Department, Agence Française de Lutte contre le Dopage (AFLD), 8 rue Auber, 75009, Paris, France.
Drug Test Anal. 2017 Nov;9(11-12):1753-1761. doi: 10.1002/dta.2185. Epub 2017 May 24.
Anti-doping controls in non-major events are relatively infrequent and athletes that compete only in these events are less likely to be controlled. The French Anti-Doping Agency carried out an anti-doping operation during a regional cycling competition in Guadeloupe. The urine and serum samples were analysed by the French anti-doping laboratory. Out of 42 athletes, 7 were positive for one or more substances prohibited by the World Anti-Doping Agency. Four serum samples contained continuous erythropoietin receptor activator (CERA) and one a recombinant erythropoietin. However, no traces were found in the corresponding urines. One of the athletes positive for CERA was also positive for growth hormone (GH), identified using the GH isoform test. The same serum was negative with the GH biomarkers test, probably because of the brief interval between injection and control (less than a day). The stimulants heptaminol and dimethylbutylamine, as well as the glucocorticoid prednisone and its metabolite prednisolone, were also found. Strikingly, 16.6% of the controlled athletes were using one or more prohibited drugs. These findings indicate that doping is widespread in athletes competing regionally and that CERA is still a popular drug for endurance sports. They underline the need for more controls, particularly blood sampling during non-major competitions. Copyright © 2017 John Wiley & Sons, Ltd.
在非重大赛事中的反兴奋剂检查相对较少，仅参加这些赛事的运动员被检查的可能性较小。法国反兴奋剂机构在瓜德罗普岛的一场地区自行车比赛期间开展了一次反兴奋剂行动。尿液和血清样本由法国反兴奋剂实验室进行分析。在42名运动员中，有7人被检测出一种或多种被世界反兴奋剂机构禁止的物质呈阳性。4份血清样本中含有连续促红细胞生成素受体激活剂（CERA），1份含有重组促红细胞生成素。然而，在相应的尿液中未发现任何痕迹。一名CERA检测呈阳性的运动员生长激素（GH）检测也呈阳性，采用GH同工型检测法进行鉴定。同一份血清的GH生物标志物检测呈阴性，可能是因为注射与检查之间的间隔时间较短（不到一天）。还发现了兴奋剂庚胺醇和二甲基丁胺，以及糖皮质激素泼尼松及其代谢物泼尼松龙。令人惊讶的是，16.6%的受检运动员使用了一种或多种违禁药物。这些发现表明，兴奋剂在参加地区性比赛的运动员中广泛存在，而且CERA仍然是耐力运动中常用的药物。它们强调了加强检查的必要性，特别是在非重大比赛期间进行血液采样。版权所有© 2017约翰·威利父子有限公司。
