梅毒性外层视网膜病变的超广角眼底自发荧光及谱域光学相干断层扫描结果
Ultra-Wide-Field Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Findings in Syphilitic Outer Retinitis.
作者信息
Saleh Mohamed G A, Campbell John Peter, Yang Paul, Lin Phoebe
出版信息
Ophthalmic Surg Lasers Imaging Retina. 2017 Mar 1;48(3):208-215. doi: 10.3928/23258160-20170301-03.
BACKGROUND AND OBJECTIVE
To determine the ultra-wide-field fundus autofluorescence (UWFFAF) and optical coherence tomography (OCT) features of syphilitic outer retinopathy (SOR).
PATIENTS AND METHODS
Retrospective chart review.
RESULTS
Three patients with SOR were investigated. Treatment with parenteral penicillin led to improvement of outer retinopathy, visual acuity, and symptoms. UWFFAF showed speckled hyperautofluorescence, hypoautofluorescence, and normal autofluorescence, similar to what has been described as a trizonal pattern in acute zonal occult outer retinopathy (AZOOR) in the chronic case of SOR, but with hyperautofluorescent areas in the two acute cases. OCT showed disruption of the photoreceptor outer segment ellipsoid zone and external limiting membrane, which improved after penicillin treatment, and corresponded to normalization of the hyperautofluorescent areas on UWFFAF. There was irregularity and nodular thickening of retinal pigment epithelium on OCT in areas of mottled hyperautofluorescence.
CONCLUSION
SOR can present similarly to AZOOR on UWFFAF and should be highly suspected in cases presenting like AZOOR. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:208-215. ].
背景与目的
确定梅毒性外层视网膜病变（SOR）的超广角眼底自发荧光（UWFFAF）和光学相干断层扫描（OCT）特征。
患者与方法
回顾性病历审查。
结果
对3例SOR患者进行了研究。胃肠外注射青霉素治疗使外层视网膜病变、视力及症状均得到改善。UWFFAF显示斑点状高自发荧光、低自发荧光及正常自发荧光，在SOR慢性病例中与急性区域性隐匿性外层视网膜病变（AZOOR）中所描述的三区模式相似，但在2例急性病例中有高自发荧光区域。OCT显示光感受器外段椭圆体带和外界膜中断，青霉素治疗后改善，且与UWFFAF上高自发荧光区域的正常化相对应。在斑点状高自发荧光区域，OCT显示视网膜色素上皮不规则及结节状增厚。
结论
SOR在UWFFAF上表现可能与AZOOR相似，在表现类似AZOOR的病例中应高度怀疑该病。[《眼科手术、激光与视网膜成像》。2017；48：208 - 215。]
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