Andrea B. Moffitt and Sandeep S. Dave, Duke University, Durham, NC.
J Clin Oncol. 2017 Mar 20;35(9):955-962. doi: 10.1200/JCO.2016.71.7603. Epub 2017 Feb 13.
In this review, we examine the genomic landscapes of lymphomas that arise from B, T, and natural killer cells. Lymphomas represent a striking spectrum of clinical behaviors. Although some lymphomas are curable with standard therapy, the majority of the affected patients succumb to their disease. Here, the genetic underpinnings of these heterogeneous entities are reviewed. We consider B-cell lymphomas, including Burkitt lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma, and primary mediastinal B-cell lymphoma. We also examine T-cell lymphomas, including anaplastic large-cell lymphoma, angioimmunoblastic T-cell lymphoma, cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma, and other peripheral T-cell lymphomas. Together, these malignancies make up most lymphomas diagnosed around the world. Genomic technologies, including microarrays and next-generation sequencing, have enabled a better understanding of the molecular underpinnings of these cancers. We describe the broad genomics findings that characterize these lymphoma types and discuss new therapeutic opportunities that arise from these findings.
在这篇综述中，我们研究了源自 B 细胞、T 细胞和自然杀伤细胞的淋巴瘤的基因组景观。淋巴瘤表现出显著的临床行为谱。尽管一些淋巴瘤可以通过标准治疗治愈，但大多数受影响的患者仍死于该疾病。在这里，我们回顾了这些异质实体的遗传基础。我们考虑了 B 细胞淋巴瘤，包括伯基特淋巴瘤、弥漫性大 B 细胞淋巴瘤、霍奇金淋巴瘤和原发性纵隔 B 细胞淋巴瘤。我们还检查了 T 细胞淋巴瘤，包括间变性大细胞淋巴瘤、血管免疫母细胞性 T 细胞淋巴瘤、皮肤 T 细胞淋巴瘤、成人 T 细胞白血病/淋巴瘤和其他外周 T 细胞淋巴瘤。这些恶性肿瘤共同构成了全球大多数诊断出的淋巴瘤。基因组技术，包括微阵列和下一代测序，使我们能够更好地了解这些癌症的分子基础。我们描述了这些淋巴瘤类型的广泛基因组学发现，并讨论了这些发现带来的新治疗机会。
