Cerino A, Bestagno M, Colonna M, Fussi F, Astaldi Ricotti G C
Istituto di Genetica Biochimica ed Evoluzionistica del C.N.R., Pavia, Italy.
Biochem Biophys Res Commun. 1988 Feb 15;150(3):931-6. doi: 10.1016/0006-291x(88)90718-8.
A polyamine derivative, carboxyethyl - Aminobutyric Acid (CEGABA), induces the formation of a large number of Epstein-Barr Virus (EBV) transformed lymphocytes, when added to the culture medium immediately after EBV infection. However, CEGABA shows only a moderate effect on the stability of EBV-transformed cell lines over time, and does not affect the growth of stabilized cell lines. It is possible that CEGABA acts on cells other than EBV transformed lymphocytes (in fact, after EBV infection all types of mononuclear cells from the blood are present in the culture) and indirectly promotes the growth of EBV transformed lymphocytes.
一种多胺衍生物，羧乙基 - 氨基丁酸（CEGABA），在EB病毒（EBV）感染后立即添加到培养基中时，可诱导大量EBV转化淋巴细胞的形成。然而，CEGABA对EBV转化细胞系随时间的稳定性仅显示出中等程度的影响，并且不影响稳定细胞系的生长。CEGABA有可能作用于EBV转化淋巴细胞以外的细胞（事实上，EBV感染后培养物中存在血液中的所有类型单核细胞），并间接促进EBV转化淋巴细胞的生长。
