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来自深海细菌芽孢杆菌属YR247的抗真菌肽化合物。

Antifungal peptidic compound from the deep-sea bacterium Aneurinibacillus sp. YR247.

作者信息

Kurata Atsushi, Yamaura Yuto, Tanaka Takumi, Kato Chiaki, Nakasone Kaoru, Kishimoto Noriaki

机构信息

Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara City, Nara, 631-8505, Japan.

Department of Marine Biodiversity Research, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima, Yokosuka, 237-0061, Japan.

出版信息

World J Microbiol Biotechnol. 2017 Apr;33(4):73. doi: 10.1007/s11274-017-2239-0. Epub 2017 Mar 15.

DOI:10.1007/s11274-017-2239-0
PMID:28299556
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5352791/
Abstract

Aneurinibacillus: sp. YR247 was newly isolated from the deep-sea sediment inside the Calyptogena community at a depth of 1171 m in Sagami Bay. The strain exhibited antifungal activity against the filamentous fungus Aspergillus brasiliensis NBRC9455. A crude extract prepared from the YR247 cells by ethanol extraction exhibited broad antimicrobial activities. The antifungal compound is stable at 4-70 °C and pH 2.0-12.0. After treatment with proteinase K, the antifungal activity was not detected, indicating that the antifungal compound of strain YR247 is a peptidic compound. Electrospray ionization mass spectrometry of the purified antifungal compound indicated that the peptidic compound has an average molecular weight of 1167.9. The molecular weight of the antifungal compound from strain YR247 is different from those of antimicrobial peptides produced by the related Aneurinibacillus and Bacillus bacteria. The antifungal peptidic compound from the deep-sea bacterium Aneurinibacillus sp. YR247 may be useful as a biocontrol agent.

摘要

嗜胨芽孢杆菌

YR247菌株是从相模湾1171米深处的Calyptogena群落深海沉积物中新分离出来的。该菌株对丝状真菌巴西曲霉NBRC9455具有抗真菌活性。通过乙醇提取从YR247细胞制备的粗提物具有广泛的抗菌活性。该抗真菌化合物在4-70°C和pH 2.0-12.0条件下稳定。用蛋白酶K处理后，未检测到抗真菌活性，这表明YR247菌株的抗真菌化合物是一种肽类化合物。纯化的抗真菌化合物的电喷雾电离质谱表明，该肽类化合物的平均分子量为1167.9。来自YR247菌株的抗真菌化合物的分子量与相关嗜胨芽孢杆菌和芽孢杆菌产生的抗菌肽的分子量不同。来自深海细菌嗜胨芽孢杆菌YR247的抗真菌肽类化合物可能用作生物防治剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/baa1921e7efc/11274_2017_2239_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/2ee75234fce9/11274_2017_2239_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/9cfc425cade4/11274_2017_2239_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/baa1921e7efc/11274_2017_2239_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/2ee75234fce9/11274_2017_2239_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/9cfc425cade4/11274_2017_2239_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83a/5352791/baa1921e7efc/11274_2017_2239_Fig3_HTML.jpg

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