Morshedloo Mohammad Reza, Quassinti Luana, Bramucci Massimo, Lupidi Giulio, Maggi Filippo
a Faculty of Agriculture, Department of Horticulture , University of Maragheh , Maragheh , Iran.
b School of Pharmacy , University of Camerino , Camerino , Italy.
Nat Prod Res. 2017 Dec;31(24):2857-2864. doi: 10.1080/14786419.2017.1303699. Epub 2017 Mar 16.
Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultivated in Iran, together with the evaluation of its antioxidant and cytotoxic activities. The essential oil composition was dominated by bioactive sesquiterpenes, namely β-elemene, bicyclogermacrene, germacrene D and (E)-caryophyllene. The oil exhibited moderate radical scavenging activity towards the [Formula: see text] radical, and mild non-selective inhibitory effects against A375, MDA-MB 231 and T98 G tumour cell lines. The latter were influenced by the presence of the anticancer β-elemene. These results provided new insights for potential application of M. grandiflora volatile oil in the pharmaceutical and cosmetics industry where only the non-volatile magnolol and honokiol have hitherto been fully exploited.
广玉兰（木兰科）是一种常绿乔木，花朵芬芳艳丽，原产于美国东南部，但在世界各地广泛种植，并用于化妆品行业治疗皮肤病。在此，我们报告了对从伊朗种植的植物花朵中提取的精油进行的化学分析，以及对其抗氧化和细胞毒性活性的评估。精油成分以生物活性倍半萜为主，即β-榄香烯、双环吉马烯、吉马烯D和（E）-石竹烯。该油对[公式：见正文]自由基表现出中等程度的自由基清除活性，对A375、MDA-MB 231和T98 G肿瘤细胞系表现出轻度的非选择性抑制作用。后者受到抗癌β-榄香烯存在的影响。这些结果为广玉兰挥发油在制药和化妆品行业的潜在应用提供了新的见解，此前在这些行业中只有非挥发性的厚朴酚和和厚朴酚得到了充分利用。
