a Laboratory Heterocyclic Chemistry, Natural Products and é (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir , University of Monastir , 5019 Monastir , Tunisia.
Nat Prod Res. 2014;28(11):769-75. doi: 10.1080/14786419.2013.879476. Epub 2014 Feb 5.
This study describes the chemical composition and evaluates the antibacterial and the cytotoxic effects of the essential oil from the flowers of Convolvulus althaeoides. Its chemical composition, determined by GC and GC-MS, is reported for the first time. A total of 24 compounds, accounting for 95.5% of the total oil, have been identified. The oil was characterised by a high proportion of sesquiterpene hydrocarbons (36.3%), followed by oxygenated sesquiterpenes (34.7%) and oxygenated monoterpenes (24.5%). The main compounds were germacrene D (12.5%), T-cadinol (11.8%) and verbenone (6.9%). The essential oil was tested for its antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis and the clinical strain Acinetobacter sp. as well as facts cytotoxic activity towards the human breast cancer cells MCF-7. This oil did not exhibit significant antibacterial activity against the tested bacteria; however, it exerted a significant cytotoxic activity against the tested cell line (IC₅₀ = 8.16 μg/mL).
本研究描述了旋覆花花朵精油的化学成分，并评估了其抗菌和细胞毒性作用。其化学成分通过 GC 和 GC-MS 进行了测定，这是首次报道。共鉴定出 24 种化合物，占总油量的 95.5%。该油的特点是含有大量的倍半萜烃（36.3%），其次是含氧倍半萜（34.7%）和含氧单萜（24.5%）。主要化合物为大根香叶烯 D（12.5%）、T-卡多醇（11.8%）和马鞭草酮（6.9%）。该精油对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、粪肠球菌和临床分离的不动杆菌以及人乳腺癌 MCF-7 细胞进行了抗菌活性测试和细胞毒性活性测试。该油对测试的细菌没有表现出显著的抗菌活性；然而，它对测试的细胞系表现出显著的细胞毒性活性（IC₅₀=8.16μg/mL）。
