Hsu P-S, Lin H-H, Li C-R, Chung W-S
Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Osteoarthritis Cartilage. 2017 Jul;25(7):1026-1031. doi: 10.1016/j.joca.2016.10.027. Epub 2017 Mar 11.
Osteoarthritis (OA) is related to carotid atherosclerosis. Few studies have investigated the incidence of cerebrovascular diseases in patients with OA. Therefore, we conducted a population-based cohort study to determine the incidence and risk of stroke in patients with OA.
We used data from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000) to investigate the incidence of stroke in 43,635 patients with OA newly diagnosed between 2002 and 2003. The non-osteoarthritis (non-OA) cohort comprised 43,635 people from the general population. The follow-up period was from the index date of OA to the date of censoring date or stroke diagnosis, or to the end of 2010.
The overall incidence of stroke was 36% higher in the OA cohort than in the non-OA cohort, with an adjusted hazard ratio (aHR) of 1.10 (95% confidence interval [CI] = 1.06-1.14) after adjustment for covariates. Men, age, comorbidity, non-selective nonsteroidal anti-inflammatory drugs (NSAIDs), and Cox-2 selective NSAIDs are independent risk factors of stroke. The OA adults with mild to moderate OA (aHR = 1.97, 95% CI = 1.70-2.28 for young adults; aHR = 1.33, 95% CI = 1.25-1.42 for middle-aged adults; aHR = 1.16, 95% CI = 1.12-1.21 for older adults) and severe OA (aHR = 3.78, 95% CI = 2.50-5.70 for young adults; aHR = 1.34, 95% CI = 1.16-1.56 for middle-aged adults; and aHR = 1.01, 95% CI = 0.92-1.10 for older adults) exhibited increased risks of stroke compared with their counterparts without OA.
OA may be associated with a slightly increased risk of stroke.
骨关节炎（OA）与颈动脉粥样硬化相关。很少有研究调查骨关节炎患者脑血管疾病的发病率。因此，我们进行了一项基于人群的队列研究，以确定骨关节炎患者中风的发病率和风险。
我们使用台湾2000年纵向健康保险数据库（LHID2000）的数据，调查了2002年至2003年间新诊断的43635例骨关节炎患者的中风发病率。非骨关节炎（非OA）队列由43635名普通人群组成。随访期从骨关节炎的索引日期至审查日期或中风诊断日期，或至2010年底。
骨关节炎队列中中风的总体发病率比非骨关节炎队列高36%，在对协变量进行调整后，调整后的风险比（aHR）为1.10（95%置信区间[CI]=1.06-1.14）。男性、年龄、合并症、非选择性非甾体抗炎药（NSAIDs）和Cox-2选择性NSAIDs是中风的独立危险因素。与无骨关节炎的同龄人相比，轻度至中度骨关节炎（年轻成年人aHR=1.97，95%CI=1.70-2.28；中年成年人aHR=1.33，95%CI=1.25-1.42；老年人aHR=1.16，95%CI=1.12-1.21）和重度骨关节炎（年轻成年人aHR=3.78，95%CI=2.50-5.70；中年成年人aHR=1.34，95%CI=1.16-1.56；老年人aHR=1.01，95%CI=0.92-1.10）的骨关节炎成年人中风风险增加。
骨关节炎可能与中风风险略有增加有关。
