State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
ACS Nano. 2017 Apr 25;11(4):3797-3805. doi: 10.1021/acsnano.6b08720. Epub 2017 Mar 21.
Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide (TDI)-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent. As an exploratory paradigm in seeking biomedical applications, TDI was modified with poly(acrylic acid)s (PAAs), resulting in eight-armed, star-like TPAs composed of an outside hydrophilic PAA corona and an inner hydrophobic TDI core. TNMs were readily fabricated via spontaneous self-assembly. Without additional vehicle and cargo, the as-prepared TNMs possessed a robust nanostructure and high photothermal conversion efficiency up to approximately 41%. The intrinsic theranostic properties of TNMs for use in photoacoustic (PA) imaging by a multispectral optoacoustic tomography system and in mediating photoinduced tumor ablation were intensely explored. Our results suggested that the TNMs could be successfully exploited as intrinsic theranostic agents for PA imaging-guided efficient tumor PTT. Thus, these TNMs hold great potential for (pre)clinical translational development.
用于光热治疗 (PTT) 的可激活治疗性纳米医学因其作为传统治疗方法的潜在临床替代物而受到持续关注。然而，治疗性纳米医学广泛存在不稳定性和复杂的纳米结构，这阻碍了其潜在的临床应用。在此，我们展示了一种基于噻吩二酰亚胺 (TDI) - 聚丙烯酸 (TPA) 的纳米医学 (TNM) 平台，可用作内在的治疗和诊断试剂。作为寻求生物医学应用的探索性范例，TDI 被聚（丙烯酸）（PAAs）修饰，形成由外部亲水性 PAA 冠和内部疏水性 TDI 核组成的八臂星形 TPAs。TNMs 可通过自发自组装轻松制备。无需额外的载体和货物，所制备的 TNMs 具有强大的纳米结构和高达约 41%的高光热转换效率。通过多光谱光声断层扫描系统对 TNMs 进行光声 (PA) 成像的内在治疗和诊断特性以及介导光诱导肿瘤消融的内在治疗和诊断特性进行了深入研究。我们的结果表明，TNMs 可成功用作 PA 成像引导的高效肿瘤 PTT 的内在治疗和诊断试剂。因此，这些 TNMs 具有很大的（前）临床转化开发潜力。
