Li Mengjie, Tse Lap Ah, Chan Wing-Cheong, Kwok Chi-Hei, Leung Siu-Lan, Wu Cherry, Yu Wai-Cho, Lee Priscilla Ming-Yi, Tsang Koon-Ho, Law Sze-Hong, Vermeulen Roel, Gu Fangyi, Caporaso Neil E, Yu Ignatius Tak-Sun, Wang Feng, Yang Xiaohong Rose
JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
Department of Surgery, North District Hospital, Hong Kong SAR, China.
Breast Cancer Res. 2017 Mar 17;19(1):31. doi: 10.1186/s13058-017-0821-x.
A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits after 10 p.m. and breast cancer in Hong Kong women.
A hospital-based case-control study was conducted during 2012-2015. A total of 922 patients with incident breast cancer (cases) and 913 hospital controls were recruited and interviewed using a standard questionnaire including information on eating behavior during both daytime and nighttime. We collected the timing, duration, types and frequencies of food intake of eating at nighttime. Odds ratios (ORs) for the risk of breast cancer in relation to nighttime eating-related variables were calculated by unconditional multivariable logistic regression.
Eating at night after 10 pm was significantly associated with breast cancer with an adjusted OR of 1.50 (95% confidence interval (CI) 1.06-2.12, P = 0.02), and the associations were stronger in women who had the longest duration of nighttime eating (≥20 years) (adjusted OR = 2.28 (95% CI 1.13-4.61, P = 0.02) and who ate late (midnight to 2 a.m.) (adjusted OR = 2.73, 95% CI 1.01-6.99, P = 0.04). Interestingly, nighttime eating was only associated with breast cancer among women who consumed staple foods (OR = 2.16, 95% CI 1.42-3.29, P < 0.001) but not those who ate vegetables or fruits as nighttime meals. The significant association between nighttime eating and breast cancer was observed among women with body mass index (BMI) <25 (OR = 2.29, 95% CI 1.48-3.52, P < 0.001) but not among women with BMI ≥25.
Results from this study suggest a possible association between nighttime eating behavior and breast cancer. These findings need to be confirmed by independent large studies.
一项新的研究表明，夜间进食可能会产生多种与乳腺癌高度相关的代谢后果。我们调查了香港女性晚上10点后夜间饮食习惯与乳腺癌之间的关联。
2012年至2015年进行了一项基于医院的病例对照研究。共招募了922例新发乳腺癌患者（病例组）和913名医院对照，并使用标准问卷进行访谈，问卷包括白天和夜间饮食行为的信息。我们收集了夜间进食的时间、时长、食物类型和频率。通过无条件多变量逻辑回归计算与夜间进食相关变量的乳腺癌风险比值比（OR）。
晚上10点后进食与乳腺癌显著相关，调整后的OR为1.50（95%置信区间（CI）1.06 - 2.12，P = 0.02）；在夜间进食时间最长（≥20年）的女性中这种关联更强（调整后的OR = 2.28（95% CI 1.13 - 4.61, P = 0.02），以及进食较晚（午夜至凌晨2点）者中也是如此（调整后的OR = 2.73，95% CI 1.01 - 6.99，P = 0.04）。有趣的是，夜间进食仅在食用主食的女性中与乳腺癌相关（OR = 2.16，95% CI 1.42 - 3.29, P < 0.001）, 而在以蔬菜或水果作为夜宵的女性中则不然。在体重指数（BMI）<25的女性中观察到夜间进食与乳腺癌之间存在显著关联（OR = 2.29，95% CI 1.48 - 3.52, P < 0.001），而在BMI≥25的女性中则未观察到这种关联。
本研究结果提示夜间进食行为与乳腺癌之间可能存在关联。这些发现需要通过独立的大型研究来证实。
