Divisions of Cancer Control and Population Sciences, National Cancer Institute at the National Institutes of Health, Rockville, MD, USA.
Division of Cancer Prevention, National Cancer Institute at the National Institutes of Health, Rockville, MD, USA.
JNCI Cancer Spectr. 2022 May 2;6(3). doi: 10.1093/jncics/pkac032.
Metabolic syndrome consists of a constellation of clinical factors associated with an increased risk of cardiovascular disease, type 2 diabetes, and cancer. Preclinical studies demonstrate that restricting the time during a 24-hour period when an obese animal eats (time-restricted feeding) leads to metabolic benefits. These benefits, which may or may not be associated with weight loss, often lead to improvements in glucose tolerance and insulin sensitivity. Studies seeking to determine whether similar benefits result when humans restrict daily eating time (time-restricted eating) are less mature and less consistent in their findings. In this commentary, we outline some of the exciting preclinical findings, the challenges that preliminary studies in humans present, and efforts of the US National Institutes of Health and specifically the National Cancer Institute to address the role of time-restricted eating in cancer.
代谢综合征由一系列与心血管疾病、2 型糖尿病和癌症风险增加相关的临床因素组成。临床前研究表明，限制肥胖动物在 24 小时内进食的时间（限时喂养）可带来代谢益处。这些益处可能与体重减轻有关，也可能无关，通常可改善葡萄糖耐量和胰岛素敏感性。旨在确定人类限制每日进食时间（限时进食）是否会产生类似益处的研究尚不成熟，结果也不一致。在这篇评论中，我们概述了一些令人兴奋的临床前发现、人类初步研究带来的挑战，以及美国国立卫生研究院特别是美国国家癌症研究所为解决限时进食在癌症中的作用所做的努力。
