Hieda Ayato, Uemura Naoya, Hashimoto Yoshiya, Toda Isumi, Baba Shunsuke
Department of Oral Implantology, Osaka Dental University.
Dent Mater J. 2017 Mar 31;36(2):222-229. doi: 10.4012/dmj.2016-277. Epub 2017 Mar 8.
The in vivo bioactivity of porous polyetheretherketone (PEEK) with a foamed surface was evaluated using rabbit femoral bone. Cylindrical porous PEEK scaffolds, with pore diameter of 550 μm and porosity of 70%, were first prepared and immersed in 98% sulfuric acid, and then washed and immersed in 3 M potassium carbonate solution used as a foaming reagent. Numerous open pores of various sizes, as well as new functional groups, were visualized on the treated PEEK surface by scanning electron microscopy and X-ray photoelectron spectroscopy, respectively. Micro computed tomography (micro-CT) showed that the volumetric density of treated PEEK was higher than that of bare PEEK at 8 weeks after surgery (p<0.05). Additionally, von Kossa staining indicated ingrowth of mature new bone tissue at 4 weeks relative to the bare PEEK group. Our data indicate that surface-treated PEEK exhibited improved bioactivity in vivo.
使用兔股骨对具有泡沫表面的多孔聚醚醚酮（PEEK）的体内生物活性进行了评估。首先制备孔径为550μm、孔隙率为70%的圆柱形多孔PEEK支架，将其浸入98%的硫酸中，然后洗涤并浸入用作发泡剂的3M碳酸钾溶液中。通过扫描电子显微镜和X射线光电子能谱分别在处理后的PEEK表面观察到了许多大小各异的开孔以及新的官能团。显微计算机断层扫描（micro-CT）显示，术后8周时，处理后的PEEK的体积密度高于裸PEEK（p<0.05）。此外，冯·科萨染色表明，相对于裸PEEK组，在4周时成熟的新骨组织向内生长。我们的数据表明，表面处理后的PEEK在体内表现出更好的生物活性。
