Ma Zhangyu, Zhao Xingyu, Zhao Jing, Zhao Zhilong, Wang Qihui, Zhang Congxiao
Department of Stomatology, The First Hospital of Jilin University, Changchun, China.
Department of Bone and Joint Surgery, The First Hospital of Jilin University, Changchun, China.
Front Bioeng Biotechnol. 2020 Dec 18;8:620537. doi: 10.3389/fbioe.2020.620537. eCollection 2020.
Polyether ether ketone (PEEK) is a non-toxic polymer with elastic modulus close to human bone. Compared with metal implants, PEEK has advantages such as evasion of stress shielding effect, easy processing, and similar color as teeth, among others. Therefore, it is an excellent substitute material for titanium dental orthopedic implants. However, PEEK's biological inertia limits its use as an implant. To change PEEK's biological inertia and increase its binding ability with bone tissue as an implant, researchers have explored a number of modification methods to enhance PEEK's biological activities such as cellular compatibility, osteogenic activity, and antibacterial activity. This review summarizes current biological activity modification methods for PEEK, including surface modification and blending modification, and analyzes the advantages and disadvantages of each modification method. We believe that modified PEEK will be a promising dental and orthopedic implant material.
聚醚醚酮（PEEK）是一种无毒聚合物，其弹性模量接近人体骨骼。与金属植入物相比，PEEK具有诸如避免应力屏蔽效应、易于加工以及颜色与牙齿相似等优点。因此，它是钛牙种植体的一种优良替代材料。然而，PEEK的生物惰性限制了其作为植入物的应用。为了改变PEEK的生物惰性并增强其作为植入物与骨组织的结合能力，研究人员探索了多种改性方法来提高PEEK的生物活性，如细胞相容性、成骨活性和抗菌活性。本综述总结了目前PEEK的生物活性改性方法，包括表面改性和共混改性，并分析了每种改性方法的优缺点。我们认为，改性后的PEEK将是一种有前途的牙科和骨科植入材料。
