镧系卟啉类作为分子诊疗试剂。
Lanthanide porphyrinoids as molecular theranostics.
机构信息
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.
Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, USA.
出版信息
Chem Soc Rev. 2022 Jul 18;51(14):6177-6209. doi: 10.1039/d2cs00275b.
In recent years, lanthanide (Ln) porphyrinoids have received increasing attention as theranostics. Broadly speaking, the term 'theranostics' refers to agents designed to allow both disease diagnosis and therapeutic intervention. This Review summarises the history and the 'state-of-the-art' development of Ln porphyrinoids as theranostic agents. The emphasis is on the progress made within the past decade. Applications of Ln porphyrinoids in near-infrared (NIR, 650-1700 nm) fluorescence imaging (FL), magnetic resonance imaging (MRI), radiotherapy, and chemotherapy will be discussed. The use of Ln porphyrinoids as photo-activated agents ('phototheranostics') will also be highlighted in the context of three promising strategies for regulation of porphyrinic triplet energy dissipation pathways, namely: regioisomeric effects, metal regulation, and the use of expanded porphyrinoids. The goal of this Review is to showcase some of the ongoing efforts being made to optimise Ln porphyrinoids as theranostics and as phototheranostics, in order to provide a platform for understanding likely future developments in the area, including those associated with structure-based innovations, functional improvements, and emerging biological activation strategies.
近年来，镧系元素（Ln）卟啉类化合物作为治疗药物和诊断试剂越来越受到关注。广义上讲，“治疗药物和诊断试剂”一词是指设计用于同时进行疾病诊断和治疗干预的试剂。本综述总结了 Ln 卟啉类化合物作为治疗药物和诊断试剂的历史和“最新”发展。重点是过去十年取得的进展。将讨论 Ln 卟啉类化合物在近红外（NIR，650-1700nm）荧光成像（FL）、磁共振成像（MRI）、放射治疗和化学治疗中的应用。还将在三种有前途的调节卟啉三重态能量耗散途径的策略的背景下，突出 Ln 卟啉类化合物作为光激活剂（“光治疗药物”）的用途，即：区域异构体效应、金属调控和使用扩展卟啉类化合物。本综述的目的是展示正在进行的一些优化 Ln 卟啉类化合物作为治疗药物和诊断试剂以及光治疗药物的努力，为理解该领域未来可能的发展提供一个平台，包括与基于结构的创新、功能改进和新兴的生物学激活策略相关的发展。
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