Lenell Charles, Johnson Aaron M
Department of Communicative Sciences and Disorders, New York University.
NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, U.S.A.
Laryngoscope. 2017 Aug;127(8):E270-E276. doi: 10.1002/lary.26561. Epub 2017 Mar 17.
The human voice is sexually dimorphic in obvious ways, such as differences in fundamental frequency and gross laryngeal anatomy, but also in less apparent ways, such as in the prevalence and types of voice disorders and the manifestation of voice changes in advanced age. Differences between males and females are rarely explored, however, in mechanistic animal studies. The goal of this study was to explore sexual dimorphism in laryngeal function and structure in adult rats by examining ultrasonic vocalization acoustics and muscle fiber size and type in the thyroarytenoid muscle.
Animal group comparison.
Spontaneous ultrasonic vocalizations from 10 male adult rats and 10 female adult rats were recorded, classified, and acoustically analyzed. Cross-sections of the thyroarytenoid muscle were stained and imaged for analysis of muscle fiber size and type. Acoustic and muscle parameters were statistically compared between sexes.
Male rats had a lower mean frequency of short ultrasonic vocalizations. Male rats also had a larger mean fiber size in the external division of the thyroarytenoid and larger overall muscle area in both the vocalis and external divisions of the thyroarytenoid. However, muscle fiber type compositions were similar between sexes in both the vocalis and external division of the thyroarytenoid muscles.
Functional and structural laryngeal differences exist between adult male and female rats; therefore, the rat model can be used to further study sexual dimorphism of the voice.
NA. Laryngoscope, 127:E270-E276, 2017.
人类嗓音在诸多方面存在性别差异，如基频和喉部大体解剖结构的不同，也存在一些不太明显的差异，如嗓音障碍的患病率和类型，以及老年时嗓音变化的表现。然而，在机制性动物研究中，很少探讨雄性和雌性之间的差异。本研究的目的是通过检查成年大鼠的超声发声声学以及甲杓肌的肌纤维大小和类型，来探索成年大鼠喉部功能和结构的性别差异。
动物组比较。
记录、分类并对10只成年雄性大鼠和10只成年雌性大鼠的自发超声发声进行声学分析。对甲杓肌的横截面进行染色和成像，以分析肌纤维大小和类型。对声学和肌肉参数进行性别间的统计学比较。
雄性大鼠短超声发声的平均频率较低。雄性大鼠甲杓肌外侧部的平均纤维大小也更大，甲杓肌声带部和外侧部的总体肌肉面积也更大。然而，甲杓肌声带部和外侧部的肌纤维类型组成在两性之间相似。
成年雄性和雌性大鼠之间存在喉部功能和结构上的差异；因此，大鼠模型可用于进一步研究嗓音的性别差异。
无。《喉镜》，2017年，第127卷，E270 - E276页。
