Pini Lorenzo, Pizzini Francesca Benedetta, Boscolo-Galazzo Ilaria, Ferrari Clarissa, Galluzzi Samantha, Cotelli Maria, Gobbi Elena, Cattaneo Annamaria, Cotelli Maria Sofia, Geroldi Cristina, Zanetti Orazio, Corbetta Maurizio, van den Heuvel Martijn, Frisoni Giovanni Battista, Manenti Rosa, Pievani Michela
Laboratory Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Neuroscience & Padova Neuroscience Center, University of Padova, Padova, Italy.
Radiology, Department of Diagnostic and Public Health, University of Verona & Department of Diagnostics and Pathology, University Hospital, Verona, Italy.
Neurobiol Aging. 2022 Mar;111:24-34. doi: 10.1016/j.neurobiolaging.2021.11.005. Epub 2021 Nov 20.
The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD.
默认模式网络（DMN）和突显网络（SN）在阿尔茨海默病（AD）和行为变异型额颞叶痴呆（bvFTD）中分别表现出功能连接减弱，同时伴有连接增强模式。我们对45例患者（AD和bvFTD）进行了针对这些网络的无创刺激，测试其临床和神经生物学效应，这些患者接受了阳极刺激（目标网络：AD中的DMN，bvFTD中的SN）或阴极刺激（目标网络：AD中的SN，bvFTD中的DMN）。我们评估了临床、认知、功能和结构连接性以及灌注指标的变化。在两组患者中，阴极刺激后行为改善，而阳极刺激导致认知改善。功能连接性和灌注均未显示出显著影响。在AD中，报告了DMN和SN功能连接性变化与刺激方案之间的显著交互作用。这些结果表明存在一种依赖于方案的反应，即所研究的方案对认知和临床指标显示出不同的影响，同时在AD中连接性的调节模式也不同。
Alzheimers Res Ther. 2022-12-29
Front Hum Neurosci. 2025-1-14
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