秋水仙碱对饰纹姬蛙胚胎作用机制的研究。
A study of the mechanism of action of colchicine on embryos ofMicrohyla ornata.
作者信息
Diwan B A
机构信息
Department of Zoology, University of Poona, India.
出版信息
Wilhelm Roux Arch Entwickl Mech Org. 1967 Jun;158(2):164-169. doi: 10.1007/BF00574017.
PMID:28304641
Abstract
- The effect of colchicine on developmental stages ofMicrohyla ornata has been studied. 2. Treatment with colchicine at early neurula stage (stage 14-15) has no effect on development. 3. Treatment with colchicine at early stages of development caused 1. Suppression of gastrulation, 2. Oedema, 3. Microcephaly, 4. Eye defects and 5. loss of pigmentation. 4. The effects of colchicine could be completely reversed by subsequent treatment with cysteine hydrochloride (2.5 μg/ml). 5. The possible modes of action of colchicine have been discussed.
摘要
- 已经研究了秋水仙碱对饰纹姬蛙发育阶段的影响。2. 在神经胚早期阶段（第14 - 15期）用秋水仙碱处理对发育没有影响。3. 在发育早期用秋水仙碱处理导致：1. 原肠胚形成受抑制，2. 水肿，3. 小头畸形，4. 眼部缺陷，5. 色素沉着丧失。4. 秋水仙碱的作用可通过随后用盐酸半胱氨酸（2.5μg/ml）处理而完全逆转。5. 已经讨论了秋水仙碱可能的作用方式。
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