Hartenstein Volker, Campos-Ortega Jose A
Institut für Entwicklungsphysiologie der Universität Köln, Gyrhofstraße 17, D-5000, Köln 41, Federal Republic of Germany.
Rouxs Arch Dev Biol. 1986 May;195(4):210-221. doi: 10.1007/BF02438953.
Mutations previously known to affect early neurogenesis inDrosophila melanogaster have been found also to affect the development of the peripheral nervous system. Anti-HRP antibody staining has shown that larval epidermal sensilla of homozygous mutant embryos occur in increased numbers, which depend on the allele considered. This increase is apparently due to the development into sensory organs of cells which in the wild-type would have developed as non-sensory epidermis. Thus, neurogenic genes act whenever developing cells have to decide between neurogenic and epidermogenic fates, both in central and peripheral nervous systems. Different regions of the ectodermal germ layer are distinguished with respect to their neurogenic abilities.
先前已知影响黑腹果蝇早期神经发生的突变，也被发现会影响外周神经系统的发育。抗辣根过氧化物酶（Anti-HRP）抗体染色显示，纯合突变胚胎的幼虫表皮感觉器数量增加，这取决于所考虑的等位基因。这种增加显然是由于原本在野生型中会发育为非感觉表皮的细胞发育成了感觉器官。因此，无论在中枢神经系统还是外周神经系统中，当发育中的细胞必须在神经源性和表皮源性命运之间做出决定时，神经发生基因都会发挥作用。外胚层胚层的不同区域在神经发生能力方面存在差异。
