Białek J, Kowalska M, Szydłowska T, Denys A
Department of Medical Microbiology, Military Medical Academy, Lódź.
Arch Immunol Ther Exp (Warsz). 1987;35(4):447-51.
The aim of the presented experiments was to estimate LIF production in the course of experimental infections with influenza viruses (of different degrees of adaptation), with S. aureus 209P and in the course of simultaneous viral-bacterial infections in mice. Spleen cells incubated with specific influenza antigens obtained according to Nath's method were used for the experiments as well as cells incubated with staphylococcal staphylolysine (Boehring Werke). The interdependence between LIF release and the degree of adaptation of viruses to lung tissue was observed. When influenza viruses APR-8 of high degree of adaptation to animal lung tissue were used, inconsiderable LIF production was observed in the early stage of observation. When the animals were infected with viruses A/Scotland/74 of low degree of adaptation, significant LIF production could be noticed since the 1st day of observation. Mixed, viral-bacterial infections influenced insignificantly LIF release. Its production was mainly conditioned by influenza viruses used for the infections.
本实验的目的是评估在小鼠感染（不同适应程度的）流感病毒、金黄色葡萄球菌209P以及同时发生病毒 - 细菌感染的过程中白血病抑制因子（LIF）的产生情况。实验使用了根据纳特方法获得的与特定流感抗原一起孵育的脾细胞，以及与葡萄球菌溶血素（宝灵曼公司生产）一起孵育的细胞。观察到LIF释放与病毒对肺组织的适应程度之间的相互关系。当使用对动物肺组织高度适应的流感病毒APR - 8时，在观察早期观察到LIF产生量较少。当动物感染适应程度低的A/苏格兰/74病毒时，从观察第一天起就可注意到显著的LIF产生。混合的病毒 - 细菌感染对LIF释放的影响不显著。其产生主要取决于用于感染的流感病毒。
