Cell phenomena in experimental viral-bacterial infections in mice. III. Estimation of the phagocytic activity of peritoneal granulocytes after in vitro contact with viral and bacterial antigens.

In the paper, the influence of in vitro contact of granulocytes with the antigen obtained from A/Scotland/74 and APR-8 influenza viruses as well as with staphylococcal anatoxine on phagocytic activity of granulocytes was examined. The results are given as phagocytic indices. In the group of animals infected with non-adapted influenza viruses the increase of phagocytosis was observed only in the first period of infection (on the 3rd and 6th day), whereas phagocytic index of granulocytes obtained from animals infected with adapted virus increased only on the 3rd day. In mixed infections, when granulocytes were contacted in vitro with viral as well as bacterial antigens, the insignificant increase of phagocytic indices was observed in the initial period of infection. On the other days of observation (on the 6th, 9th and 14th day) the obtained results approximated to values of phagocytic indices of granulocytes from the control group of animals.