Schonfeld S E
J Dent Res. 1979 Mar;58(Spec Issue B):810-6. doi: 10.1177/00220345790580023201.
Antisera to enamel proteins have been used primarily as a probe for biochemical and developmental studies of enamel proteins and tooth formation. More recently, the inherent immunogenicity of enamel protein has become a subject for investigation. Papers are reviewed which show that soluble enamel proteins are immunogenic across species barriers, and that solid-phase enamel proteins are immunogenic within a species. New data are presented which demonstrate that enamel proteins are autoantigenic both in vivo and in vitro. Future areas of research are suggested.
针对牙釉质蛋白的抗血清主要被用作牙釉质蛋白和牙齿形成的生化及发育研究的探针。最近，牙釉质蛋白固有的免疫原性已成为研究对象。本文回顾了一些论文，这些论文表明可溶性牙釉质蛋白在种间具有免疫原性，而固相牙釉质蛋白在种内具有免疫原性。本文还提供了新的数据，这些数据表明牙釉质蛋白在体内和体外均具有自身抗原性。文中还提出了未来的研究方向。
