Mendonça Marcelo D, Lampreia Tania, Miguel Rita, Caetano André, Barbosa Raquel, Bugalho Paulo
Department of Neurology, Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
CEDOC-Chronic Diseases Research Center, Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
J Neural Transm (Vienna). 2017 Jul;124(7):863-867. doi: 10.1007/s00702-017-1711-1. Epub 2017 Mar 17.
Advancing age is a well-known risk factor for Parkinson's disease (PD). With population ageing it is expected that the total number of patients with PD onset at oldage increases. Information on the motor but particularly on non-motor phenotype of this late-onset population is lacking. We recruited 24 patients with PD onset at or over 75 years. Each patient was matched with 1 control patient with PD onset between the ages of 40 and 65 and matched for disease duration. Both groups were assessed with the UPDRS, the Non-motor symptoms scale (NMSS) and other scales to assess non-motor symptoms. Groups were compared with conditional logistic regression analysis. Old-age onset PD was, on average, 80 years at the time of PD onset while middle-age onset were 59. Disease duration was approximately 5 years in both groups. While no difference was observed in the total UPDRS-III scores, old-age onset PD was associated with higher axial symptoms (7.42 vs. 4.63, p = 0.011) and a higher frequency of dementia (7/24 vs. 0/24, p = 0.009). While no difference in the total number of non-motor symptoms was observed (6.79 vs. 6.22, p = 0.310), old-age onset patients had a higher prevalence of gastrointestinal symptoms (20/24 vs. 12/24, p = 0.037). For the same disease duration, older age onset is associated with worse axial motor dysfunction and dementia in PD patients. Beside gastrointestinal symptoms, non-motor symptoms are not associated with age.
年龄增长是帕金森病（PD）众所周知的风险因素。随着人口老龄化，预计老年期发病的帕金森病患者总数会增加。目前缺乏关于这一迟发性人群运动症状，尤其是非运动症状表型的信息。我们招募了24例75岁及以上发病的帕金森病患者。每例患者与1例年龄在40至65岁之间发病的帕金森病对照患者进行匹配，并匹配疾病病程。两组均采用统一帕金森病评定量表（UPDRS）、非运动症状量表（NMSS）和其他量表来评估非运动症状。采用条件逻辑回归分析对两组进行比较。老年期发病的帕金森病患者发病时平均年龄为80岁，而中年期发病的患者为59岁。两组的疾病病程均约为5年。虽然两组在UPDRS-III总分上没有差异，但老年期发病的帕金森病与更高的轴性症状（7.42对4.63，p = 0.011）和更高的痴呆发生率（7/24对0/24，p = 0.009）相关。虽然在非运动症状总数上没有差异（6.79对6.22，p = 0.310），但老年期发病的患者胃肠道症状的患病率更高（20/24对12/24，p = 0.037）。对于相同的疾病病程，老年期发病与帕金森病患者更严重的轴性运动功能障碍和痴呆相关。除胃肠道症状外，非运动症状与年龄无关。
