Berganzo K, Tijero B, González-Eizaguirre A, Somme J, Lezcano E, Gabilondo I, Fernandez M, Zarranz J J, Gómez-Esteban J C
Grupo Enfermedades Neurodegenerativas, Unidad de trastornos del movimiento y disautonomía, BioCruces Health Research Institute, Barakaldo, Bizkaia, España.
Grupo Enfermedades Neurodegenerativas, Unidad de trastornos del movimiento y disautonomía, BioCruces Health Research Institute, Barakaldo, Bizkaia, España.
Neurologia. 2016 Nov-Dec;31(9):585-591. doi: 10.1016/j.nrl.2014.10.010. Epub 2014 Dec 17.
The aim of the present study is to analyse the influence that motor and non-motor symptoms have on the quality of life (QoL) of patients with Parkinson's disease (PD), and to study the relationship between the two types of symptoms.
This cross-sectional study included 103 patients with PD (55 men and 48 women). Quality of life was measured on the PDQ-39 scale. The UPDRS scale (I-IV) was also used, and different items were grouped to analyse the presence of tremor, rigidity, bradykinesia, and axial symptoms. The non-motor symptoms scale (NMSS) was administered to assess non-motor symptoms. We performed correlation analyses between different scales to analyse the influence of motor and non-motor symptoms on QoL.
Correlations were observed between the PDQ-39 summary index (PDQ39_SI) and the NMSS (correlation coefficient [cc], 0.56; p<.001), UPDRS III (cc, 0.44; p< .001) and UPDRS IV (cc, 0.37; p<.001) scores. The strongest correlation was between cognitive symptoms and mood. The analysis pointed to a direct relationship between the NMSS score and axial symptoms (cc, 0.384; p<.01), bradykinesia (cc, 0.299; p<.01), and to a lesser extent, rigidity (cc, 0.194; p<.05). No relationship was observed between presence of tremor and the NMSS score.
Cognitive symptoms and mood exert the most influence on QoL of patients with PD. We found at least two phenotypes; one with predominantly axial symptoms, with significant involvement of non-motor symptoms, and a tremor-associated phenotype in which these symptoms are less prevalent.
本研究旨在分析运动症状和非运动症状对帕金森病（PD）患者生活质量（QoL）的影响，并研究这两种症状之间的关系。
这项横断面研究纳入了103例PD患者（55例男性和48例女性）。使用PDQ-39量表测量生活质量。还使用了UPDRS量表（I-IV），并将不同项目分组以分析震颤、强直、运动迟缓及轴性症状的存在情况。采用非运动症状量表（NMSS）评估非运动症状。我们对不同量表进行相关性分析，以分析运动症状和非运动症状对生活质量的影响。
观察到PDQ-39总指数（PDQ39_SI）与NMSS（相关系数[cc]，0.56；p<0.001）、UPDRS III（cc，0.44；p<0.001）和UPDRS IV（cc，0.37；p<0.001）得分之间存在相关性。认知症状与情绪之间的相关性最强。分析表明NMSS得分与轴性症状（cc，0.384；p<0.01）、运动迟缓（cc，0.299；p<0.01）之间存在直接关系，与强直的相关性较小（cc，0.194；p<0.05）。未观察到震颤的存在与NMSS得分之间的关系。
认知症状和情绪对PD患者的生活质量影响最大。我们发现至少有两种表型；一种以轴性症状为主，非运动症状显著受累，另一种是震颤相关表型，其中这些症状不太普遍。
