Kocatürk Tolga, Akgüllü Çağdaş, Evliçoğlu Gökhan E, Ömürlü İmran K, Çakmak Harun, Eryılmaz Ufuk, Dayanır Volkan
Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University; Aydın-Turkey.
Anatol J Cardiol. 2017 Jul;18(1):62-67. doi: 10.14744/AnatolJCardiol.2017.7562. Epub 2017 Mar 9.
The pathophysiology of glaucoma is still undisclosed. Cardiovascular hemodynamic changes are hypothesized to contribute to glaucoma. This study aimed to determine the differences in the diurnal blood pressure (BP) of patients with normal tension glaucoma (NTG), primary open angle glaucoma (POAG), and controls without glaucoma.
A total of 129 patients were included in this study. The day-night average systolic and diastolic BPs, the day-night average pulse pressures (PPs), the day-night average heart rates, and the percentage of BP decline at night were obtained from the Holter devices and compared.
Prospective, randomized, case-control study.
This study included 43 NTG patients (Group 1), 44 POAG patients (Group 2), and 42 healthy subjects without glaucoma (Group 3). The age (p=0.138) and sex (p=0.216) distributions between the groups were similar. The average day-night PP values of Group 1 were 49.17±9.90 and 46.07±10.84 mm Hg, respectively, while their total average PP was 48.48±9.60, their total average systolic BP was 120.02±12.65, and their night average systolic BP was 111.93±15.87 mm Hg. In Group 2, the average day and night PP values were 54.83±10.35 and 51.73±9.10 mm Hg, respectively, their total average PP was 54.00±9.87, their total average systolic BP was 126.75±11.50, and their night average systolic BP was 119.21±12.38 mm Hg. These differences were statistically significant and the corresponding p values were 0.040, 0.040, 0.037, 0.033, and 0.038.
NTG patients have low diurnal BP parameters, which may reduce their optic nerve perfusion and may be responsible for their glaucomatous visual field damage.
青光眼的病理生理学仍未明确。有假设认为心血管血流动力学变化与青光眼有关。本研究旨在确定正常眼压性青光眼（NTG）、原发性开角型青光眼（POAG）患者及无青光眼对照者的昼夜血压（BP）差异。
本研究共纳入129例患者。通过动态心电图监测仪获取昼夜平均收缩压和舒张压、昼夜平均脉压（PP）、昼夜平均心率以及夜间血压下降百分比，并进行比较。
前瞻性、随机、病例对照研究。
本研究纳入43例NTG患者（第1组）、44例POAG患者（第2组）和42例无青光眼的健康受试者（第3组）。各组间年龄（p = 0.138）和性别（p = 0.216）分布相似。第1组的昼夜平均PP值分别为49.17±9.90和46.07±10.84 mmHg，其总平均PP为48.48±9.60，总平均收缩压为120.02±12.65，夜间平均收缩压为111.93±15.87 mmHg。第2组的昼夜平均PP值分别为54.83±10.35和51.73±9.10 mmHg，其总平均PP为54.00±9.87，总平均收缩压为126.75±11.50，夜间平均收缩压为119.21±12.38 mmHg。这些差异具有统计学意义，相应的p值分别为0.040、0.040、0.037、0.033和0.038。
NTG患者昼夜血压参数较低，这可能会减少其视神经灌注，并可能导致其青光眼性视野损害。
