Foroozanfard Fatemeh, Rafiei Hamideh, Samimi Mansooreh, Gilasi Hamid Reza, Gorjizadeh Roohangiz, Heidar Zahra, Asemi Zatollah
Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Department of Epidemiology and Biostatistics, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran.
Clin Endocrinol (Oxf). 2017 Jul;87(1):51-58. doi: 10.1111/cen.13333. Epub 2017 Apr 11.
This study was designed to evaluate the effects of the dietary approaches to stop hypertension (DASH diet) on weight loss, anti-Müllerian hormone (AMH) and metabolic profiles in women with polycystic ovary syndrome (PCOS).
DESIGN, PATIENTS AND MEASUREMENTS: A randomized controlled clinical trial was conducted among 60 overweight or obese patients with PCOS. Patients were randomly assigned to receive either low-calorie DASH (N=30) or control diet (N=30) for 12 weeks. The DASH and control diets were consisted of 52%-55% carbohydrates, 16%-18% proteins and 30% total fats; however, the DASH diet was designed to be rich in fruits, vegetables, whole grains, low-fat dairy products, cholesterol and refined grains. Both diets were equicaloric.
Adherence to the DASH diet, compared to the control diet, resulted in a significant decrease in BMI (-1.6±0.5 vs -1.2±0.7 kg/m , P=.02). Significant decreases in AMH (-1.1±3.1 vs +0.3±0.7 ng/mL, P=.01), insulin (-25.2±51.0 vs -1.2±28.8 pmol/L, P=.02), homoeostasis model of assessment-estimated insulin resistance (-0.9±2.0 vs -0.1±1.0, P=.02), free androgen index (FAI; -0.03±0.09 vs +0.06±0.21, P=.02) and malondialdehyde (MDA) levels (-0.5±0.4 vs +0.2±0.3 μmol/L, P<.001), and significant increases in quantitative insulin sensitivity check index (+0.01±0.03 vs -0.004±0.01, P=.02), sex hormone-binding globulin (SHBG; +3.7±8.5 vs -1.5±7.2 nmol/L, P=.01) and nitric oxide (NO; +9.0±4.9 vs +0.6±2.3 μmol/L, P<.001) were also seen in the DASH group compared with the control group.
Adherence to the DASH diet for 12 weeks among PCOS women had beneficial effects on BMI, AMH, insulin metabolism, SHBG, FAI, NO and MDA levels.
本研究旨在评估采用终止高血压膳食疗法（DASH饮食）对多囊卵巢综合征（PCOS）女性体重减轻、抗苗勒管激素（AMH）及代谢谱的影响。
设计、患者与测量方法：对60例超重或肥胖的PCOS患者进行了一项随机对照临床试验。患者被随机分配接受低热量DASH饮食（N = 30）或对照饮食（N = 30），为期12周。DASH饮食和对照饮食均包含52%-55%的碳水化合物、16%-18%的蛋白质以及30%的总脂肪；然而，DASH饮食的设计富含水果、蔬菜、全谷物、低脂乳制品，胆固醇及精制谷物含量较低。两种饮食的热量相等。
与对照饮食相比，坚持DASH饮食可使体重指数显著降低（-1.6±0.5 vs -1.2±0.7kg/m²，P = 0.02）。DASH组与对照组相比，AMH（-1.1±3.1 vs +0.3±0.7ng/mL，P = 0.01）、胰岛素（-25.2±51.0 vs -1.2±28.8pmol/L，P = 0.02）、稳态模型评估-估计胰岛素抵抗（-0.9±2.0 vs -0.1±1.0，P = 0.02）、游离雄激素指数（FAI；-0.03±0.09 vs +0.06±0.21，P = 0.02）及丙二醛（MDA）水平（-0.5±0.4 vs +0.2±0.3μmol/L，P<0.001）也显著降低，而定量胰岛素敏感性检查指数（+0.01±0.03 vs -0.004±0.01，P = 0.02）、性激素结合球蛋白（SHBG；+3.7±8.5 vs -1.5±7.2nmol/L，P = 0.01）及一氧化氮（NO；+9.0±4.9 vs +0.6±2.3μmol/L，P<0.001）则显著升高。
PCOS女性坚持12周DASH饮食对体重指数（BMI）、AMH、胰岛素代谢、SHBG、FAI、NO及MDA水平具有有益影响。
