Gude Francisco, Díaz-Vidal Pablo, Rúa-Pérez Cintia, Alonso-Sampedro Manuela, Fernández-Merino Carmen, Rey-García Jesús, Cadarso-Suárez Carmen, Pazos-Couselo Marcos, García-López José Manuel, Gonzalez-Quintela Arturo
1 Clinical Epidemiology Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
2 Department of Statistics and Operations Research, Universidad de Santiago, Santiago de Compostela, Spain.
J Diabetes Sci Technol. 2017 Jul;11(4):780-790. doi: 10.1177/1932296816682031. Epub 2016 Dec 13.
The objective was to investigate glycemic variability indices in relation to demographic factors and common environmental lifestyles in a general adult population.
The A Estrada Glycation and Inflammation Study is a cross-sectional study covering 1516 participants selected by sampling of the population aged 18 years and over. A subsample of 622 individuals participated in the Glycation project, which included continuous glucose monitoring procedures. Five glycemic variability indices were analyzed, that is, SD, MAGE, MAG, CONGA1, and MODD.
Participants had a mean age of 48 years, 62% were females, and 12% had been previously diagnosed with diabetes. In the population without diabetes, index distributions were not normal but skewed to the right. Distributional regression models that adjusted for age, gender, BMI, alcohol intake, smoking status, and physical activity confirmed that all indices were positively and independently associated with fasting glucose levels and negatively with heavy drinking. SD, MAGE, and CONGA1 were positively associated with aging, and MAG was negatively associated with BMI. None of the GVI studied were influenced by physical activity. Age-group-specific reference values are given for the indices.
This study yielded age-specific reference values for glucose variability indices in a general adult population. Significant increases were observed with aging. Heavy drinking of more than 140 g/week was associated with significant decreases in variability indices. No differences were found between males and females. These normative ranges provide a guide for clinical care, and may offer an alternative treatment target among persons with diabetes.
本研究旨在调查一般成年人群中血糖变异性指标与人口统计学因素及常见环境生活方式之间的关系。
A埃斯特拉达糖化与炎症研究是一项横断面研究，涵盖了1516名18岁及以上的参与者，这些参与者是通过人群抽样选取的。622名个体的子样本参与了糖化项目，该项目包括连续血糖监测程序。分析了五个血糖变异性指标，即标准差（SD）、平均血糖波动幅度（MAGE）、平均血糖波动幅度血糖标准化值（MAG）、血糖波动连续性评估指标1（CONGA1）和平均血糖波动方向离散度（MODD）。
参与者的平均年龄为48岁，62%为女性，12%曾被诊断患有糖尿病。在无糖尿病的人群中，指标分布不正常，而是向右偏态。调整了年龄、性别、体重指数（BMI）、酒精摄入量、吸烟状况和身体活动的分布回归模型证实，所有指标均与空腹血糖水平呈正相关且独立相关，与大量饮酒呈负相关。SD、MAGE和CONGA1与衰老呈正相关，而MAG与BMI呈负相关。所研究的血糖变异性指标均不受身体活动的影响。给出了各指标按年龄组划分的参考值。
本研究得出了一般成年人群血糖变异性指标的年龄特异性参考值。随着年龄增长，观察到显著增加。每周饮酒超过140克与变异性指标显著降低有关。男性和女性之间未发现差异。这些规范范围为临床护理提供了指导，并可能为糖尿病患者提供替代治疗目标。
