Grudyanov A I, Tkacheva O N, Avraamova T V
Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia, National Research Center for Preventive Medicine, Ministry of Health of Russia, Moscow, Russia.
Stomatologiia (Mosk). 2017;96(1):4-7. doi: 10.17116/stomat20179614-7.
The aim of the study was to assess correlative risk of progression of inflammatory periodontal lesions, the development of a systemic inflammatory reaction and cardiovascular diseases. The study involved 89 patients with chronic periodontal disease (CPD) of varying degrees. High cardiovascular disease risk was revealed in 8.8% of patients with moderate and 13.3% of patients with severe periodontal disease. It is proved that an additional factor contributing to the pathogenic relationship between periodontal inflammatory changes and the development of cardiovascular disease is systemic inflammatory response with increased hrC-reactive protein >3.4 mg/l and interleukin-6 to11.0±3.4 mg/l. Changes of blood lipid spectrum with a reduction in apolipoprotein A1 were associated with progression and development of the CPD. Correlations of somatic and dental pathology requires dentists and cardiologists joint efforts to modify common risk factors.
该研究的目的是评估炎症性牙周病变进展、全身炎症反应发展以及心血管疾病之间的相关风险。该研究纳入了89例不同程度慢性牙周病（CPD）患者。中度牙周病患者中有8.8%、重度牙周病患者中有13.3%存在高心血管疾病风险。已证实，导致牙周炎症变化与心血管疾病发展之间致病关系的另一个因素是全身炎症反应，即高敏C反应蛋白>3.4 mg/l且白细胞介素-6达到11.0±3.4 mg/l。载脂蛋白A1降低时血脂谱的变化与CPD的进展和发展相关。躯体病理学和牙科病理学之间的相关性需要牙医和心脏病专家共同努力来改变共同的风险因素。
