Periodontal Medicine Research Group, Dentistry School, Universidad del Valle, Cali, Colombia; School of Health Sciences, Universidad del Valle, Cali, Colombia.
Aust Dent J. 2014 Mar;59(1):29-36. doi: 10.1111/adj.12139. Epub 2014 Feb 4.
The aim of this study was to evaluate the endothelial function, systemic inflammatory biomarkers and subgingival microbial profile associations in patients with and without periodontal disease.
Forty-four patients, half with chronic moderate to severe periodontitis (cases) and half gingivitis and incipient periodontitis (controls) were recruited. Anthropometric, clinical, biochemical parameters, endothelial function, subgingival microbiota, and eight plasma biomarkers of cardiovascular disease were assessed in both groups.
Both groups were comparable in anthropometric parameters, blood pressure, and number of positive metabolic syndrome components. Univariate analyses demonstrated significantly higher plasma levels of E-selectin (64.5 ± 30.9 vs 43.8 ± 22.2; P = 0.026) and myeloperoxidase (MPO) (103 ± 114.5 vs 49.1 ± 35.6; P = 0.032) in cases than controls. In addition, significantly higher levels of E-selectin, MPO and ICAM-1 were found in periodontitis patients after adjustment by age and waist circumference. Red complex microorganisms were more frequently detected by culture and polymerase chain reaction in patients with severe to moderate periodontitis.
Subgingival red complex bacteria and important cardiovascular risk markers were increased in untreated chronic moderate to severe periodontitis cases. Periodontitis seems to be associated with systemic inflammation that could increase the risk of cardiovascular events. The causal relation between periodontal infections and cardiovascular disease requires further research.
本研究旨在评估牙周病患者和非牙周病患者的内皮功能、系统性炎症生物标志物和龈下微生物谱的相关性。
招募了 44 名患者，其中一半患有慢性中重度牙周炎（病例组），另一半患有牙龈炎和早期牙周炎（对照组）。对两组患者进行了人体测量、临床、生化参数、内皮功能、龈下微生物群和 8 种心血管疾病的血浆生物标志物评估。
两组在人体测量参数、血压和代谢综合征阳性成分数量方面无差异。单因素分析显示，病例组的血浆 E-选择素（64.5±30.9 比 43.8±22.2；P=0.026）和髓过氧化物酶（MPO）（103±114.5 比 49.1±35.6；P=0.032）水平显著高于对照组。此外，在调整年龄和腰围后，牙周炎患者的 E-选择素、MPO 和 ICAM-1 水平显著升高。严重至中度牙周炎患者的培养和聚合酶链反应检测到更多的红色复合体微生物。
未经治疗的慢性中重度牙周炎病例中，龈下红色复合体细菌和重要的心血管风险标志物增加。牙周炎似乎与全身炎症有关，这可能会增加心血管事件的风险。牙周炎感染与心血管疾病之间的因果关系需要进一步研究。
