Chen J, Zhou Y, Nie J, Wang Y, Zhang L, Shi Q, Tan H, Kong W
Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
Department of Endocrinology,Third Affiliate Hospital of Guangzhou Medical University,Guang Zhou,China.
J Laryngol Otol. 2017 Jun;131(6):523-528. doi: 10.1017/S0022215117000524. Epub 2017 Mar 20.
Chronic rhinosinusitis is a common nasal disorder in children that is prone to recurrence. This study investigated the prevention of chronic rhinosinusitis recurrence with bacteria lysate in children.
Bacteria lysate was administered 10 days per month for 3 months to children with chronic rhinosinusitis, who had just entered a remission phase. Visual analogue score, nasal symptoms scores, rhinitis attack frequency and antibiotic use were assessed at three months and one year.
At one year of follow up, the visual analogue score, nasal discharge and obstruction scores, number of days with rhinitis attacks per month and number of days with antibiotic use per month were significantly decreased in the prevention group versus the control group (p < 0.05).
Bacterial lysate used in the remission period of rhinosinusitis in children was shown to provide long-term prophylaxis. Bacterial lysate can effectively reduce the frequency of rhinosinusitis attacks and ameliorate attack symptoms.
慢性鼻-鼻窦炎是儿童常见的鼻部疾病，易于复发。本研究调查了细菌溶解产物对儿童慢性鼻-鼻窦炎复发的预防作用。
对刚进入缓解期的慢性鼻-鼻窦炎患儿，每月给予细菌溶解产物治疗10天，持续3个月。在3个月和1年时评估视觉模拟评分、鼻部症状评分、鼻炎发作频率和抗生素使用情况。
随访1年时，预防组的视觉模拟评分、鼻分泌物和鼻塞评分、每月鼻炎发作天数和每月抗生素使用天数与对照组相比显著降低（p<0.05）。
儿童鼻-鼻窦炎缓解期使用细菌溶解产物可提供长期预防作用。细菌溶解产物可有效降低鼻-鼻窦炎发作频率并改善发作症状。
