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胃硬癌肿瘤细胞中I型前胶原的免疫组织化学鉴定

Immunohistochemical identification of type I procollagen in tumour cells of scirrhous adenocarcinoma of the stomach.

作者信息

Niitsu Y, Ito N, Kohda K, Owada M, Morita K, Sato S, Watanabe N, Kohgo Y, Urushizaki I

机构信息

Department of Internal Medicine, Sapporo Medical College, Japan.

出版信息

Br J Cancer. 1988 Jan;57(1):79-82. doi: 10.1038/bjc.1988.13.

DOI:10.1038/bjc.1988.13
PMID:2831927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2246690/
Abstract

Human gastric carcinomas were tested for their immunohistochemical reactivity with anti-type I procollagen antiserum. In all specimens of scirrhous carcinomas, staining of the tumour cells was strongly positive, while in medullary carcinomas staining of the tumour cells was generally poor. These results suggest that the tumour cells in scirrhous carcinomas produce collagen in their stroma.

摘要

采用抗I型前胶原抗血清对人胃癌进行免疫组化反应检测。在所有硬癌标本中，肿瘤细胞染色呈强阳性，而在髓样癌中，肿瘤细胞染色通常较弱。这些结果表明，硬癌中的肿瘤细胞在其基质中产生胶原蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/c220d2b2d3e8/brjcancer00135-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/ed54bbee48f5/brjcancer00135-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/266a3c50cff6/brjcancer00135-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/ac1c8364f6e2/brjcancer00135-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/c220d2b2d3e8/brjcancer00135-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/ed54bbee48f5/brjcancer00135-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/266a3c50cff6/brjcancer00135-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/ac1c8364f6e2/brjcancer00135-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adfd/2246690/c220d2b2d3e8/brjcancer00135-0090-a.jpg

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Cancer Sci. 2014 Feb;105(2):228-35. doi: 10.1111/cas.12329. Epub 2014 Jan 8.
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Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer.浸润的粒细胞中转化生长因子-β的过表达与胰腺癌中胶原蛋白mRNA的表达相关。
Br J Cancer. 2004 Oct 4;91(7):1316-26. doi: 10.1038/sj.bjc.6602141.
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Breast tumour cell-induced down-regulation of type I collagen mRNA in fibroblasts.

本文引用的文献

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Biosynthesis of an interstitial type of collagen by cloned human gastric carcinoma cells.克隆的人胃癌细胞合成间质型胶原蛋白。
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Transforming growth factor beta 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue.从硬癌胃癌细胞分泌的转化生长因子β1与组织中过量的胶原沉积有关。
Br J Cancer. 1994 Apr;69(4):777-83. doi: 10.1038/bjc.1994.147.
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Nihon Shokakibyo Gakkai Zasshi. 1984 Nov;81(11):2729-37.
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Br J Cancer. 1975 Jun;31(6):653-60. doi: 10.1038/bjc.1975.112.