胃硬癌肿瘤细胞中I型前胶原的免疫组织化学鉴定

Niitsu Y, Ito N, Kohda K, Owada M, Morita K, Sato S, Watanabe N, Kohgo Y, Urushizaki I

Department of Internal Medicine, Sapporo Medical College, Japan.

Br J Cancer. 1988 Jan;57(1):79-82. doi: 10.1038/bjc.1988.13.

Human gastric carcinomas were tested for their immunohistochemical reactivity with anti-type I procollagen antiserum. In all specimens of scirrhous carcinomas, staining of the tumour cells was strongly positive, while in medullary carcinomas staining of the tumour cells was generally poor. These results suggest that the tumour cells in scirrhous carcinomas produce collagen in their stroma.

采用抗I型前胶原抗血清对人胃癌进行免疫组化反应检测。在所有硬癌标本中，肿瘤细胞染色呈强阳性，而在髓样癌中，肿瘤细胞染色通常较弱。这些结果表明，硬癌中的肿瘤细胞在其基质中产生胶原蛋白。