Uehara Y, Takahashi T, Kojima O, Majima T, Fujita Y
Jpn J Surg. 1986 Jul;16(4):245-9. doi: 10.1007/BF02470932.
Tissue specimens from patients with the scirrhous type of gastric carcinoma were stained using the peroxidase-antiperoxidase (PAP) method. Nine out of thirty-seven specimens (24 per cent) showed positive estrogen staining, and here tissues from male or older patients were usually stained. Cumulative survival rate in patients whose tissue showed a positive estrogen staining was higher than that in case of a negative estrogen staining. Four out of thirty-one specimens (13 per cent) stained positively for progesterone, all four patients being male. These results suggest that estrogen and progesterone may relate to the growth of the scirrhous type of gastric cancer.
采用过氧化物酶-抗过氧化物酶（PAP）法对硬癌型胃癌患者的组织标本进行染色。37份标本中有9份（24%）显示雌激素染色阳性，且男性或老年患者的组织通常染色。组织雌激素染色阳性患者的累积生存率高于雌激素染色阴性患者。31份标本中有4份（13%）孕激素染色阳性，所有4例患者均为男性。这些结果表明，雌激素和孕激素可能与硬癌型胃癌的生长有关。
