Song Hang, Zhang Mingzhou, Hu Xiaodan, Li Kaixiu, Jiang Xiaodan, Liu Yan, Lv Huibin, Li Xuemin
Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
J Ophthalmol. 2017;2017:1247138. doi: 10.1155/2017/1247138. Epub 2017 Feb 20.
. To analyze the correlations between the ocular surface signs and symptoms in patients with dry eye. In this observational study, 176 dry eye patients, including 60 males and 116 females, were enrolled and their dry eye symptoms and ocular signs were observed. Partial correlation analysis was conducted between OSDI score and each ocular surface sign, and the correlations were further discussed in different age groups. Then multiple linear regression analysis was used to further explore the influence of these signs on OSDI score. . Our correlation analyses showed that rounding of lid margins, notching of lid margins, vascularity of lid margins, hyperkeratinization, plugging of orifices, main duct dropout, and conjunctival congestion all had a positive correlation with OSDI score, while main duct number (central 1 cm) and BUT had a negative one. Further analysis suggested that these correlations varied in different age groups. Multiple linear regression analysis indicated that main duct number (central 1 cm), rounding of lid margins, and hyperkeratinization significantly affected OSDI score. . Close attention should be paid to the morphology and structure of the eyelid margin and the function of meibomian gland in the diagnosis, treatment, and follow-up of dry eye diseases.
分析干眼患者眼表体征与症状之间的相关性。在这项观察性研究中，纳入了176例干眼患者，其中男性60例，女性116例，观察他们的干眼症状和眼表体征。对眼表疾病指数（OSDI）评分与每个眼表体征进行偏相关分析，并在不同年龄组中进一步讨论相关性。然后采用多元线性回归分析进一步探讨这些体征对OSDI评分的影响。我们的相关性分析表明，睑缘圆钝、睑缘切迹、睑缘血管化、角化过度、管口堵塞、主导管缺失和结膜充血均与OSDI评分呈正相关，而主导管数量（中央1cm）和泪膜破裂时间（BUT）呈负相关。进一步分析表明，这些相关性在不同年龄组中有所不同。多元线性回归分析表明，主导管数量（中央1cm）、睑缘圆钝和角化过度显著影响OSDI评分。在干眼疾病的诊断、治疗和随访中，应密切关注睑缘的形态结构和睑板腺的功能。
