Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, Ontario, Canada.
Pathol Res Pract. 2021 Jan;217:153314. doi: 10.1016/j.prp.2020.153314. Epub 2020 Dec 4.
Cancer cells are able to undergo aerobic glycolysis and metabolize glucose to lactate instead of oxidative phosphorylation, which is known as Warburg effect. Accumulating evidence has revealed that microRNAs regulate cancer cell metabolism, which manifest a higher rate of glucose metabolism. Various signaling pathways along with glycolytic enzymes are responsible for the emergence of glycolytic dependence. MicroRNAs are a class of non-coding RNAs that are not translated into proteins but regulate target gene expression or in other words function pre-translationally and post-transcriptionally. MicroRNAs have been shown to be involved in various biological processes, including glucose metabolism via targeting major transcription factors, enzymes, oncogenes or tumor suppressors alongside the oncogenic signaling pathways. In this review, we describe the regulatory role of microRNAs of cancer cell glucose metabolism, including in the glucose uptake, glycolysis, tricarboxylic acid cycle and several signaling pathways and further suggest that microRNA-based therapeutics can be used to inhibit the process of glucose metabolism reprogramming in cancer cells and thus suppressing cancer progression.
癌细胞能够进行有氧糖酵解，将葡萄糖代谢为乳酸，而不是氧化磷酸化，这被称为瓦博格效应。越来越多的证据表明，microRNAs 调节癌细胞代谢，表现出更高的葡萄糖代谢率。各种信号通路以及糖酵解酶负责产生糖酵解依赖性。microRNAs 是一类非编码 RNA，它们不翻译成蛋白质，而是调节靶基因的表达，换句话说，它们在翻译前和转录后发挥作用。microRNAs 被证明参与了各种生物过程，包括通过靶向主要转录因子、酶、癌基因或肿瘤抑制因子以及致癌信号通路来调节葡萄糖代谢。在这篇综述中，我们描述了 microRNAs 对癌细胞葡萄糖代谢的调节作用，包括葡萄糖摄取、糖酵解、三羧酸循环以及几种信号通路，并进一步提出基于 microRNA 的治疗方法可用于抑制癌细胞葡萄糖代谢重编程过程，从而抑制癌症进展。
