Popescu Corneliu P, Florescu Simin A, Lupulescu Emilia, Zaharia Mihaela, Tardei Gratiela, Lazar Mihaela, Ceausu Emanoil, Ruta Simona M
Emerg Infect Dis. 2017 Apr;23(4):574-581. doi: 10.3201/eid2304.161317.
We characterized influenza B virus-related neurologic manifestations in an unusually high number of hospitalized adults at a tertiary care facility in Romania during the 2014-15 influenza epidemic season. Of 32 patients with a confirmed laboratory diagnosis of influenza B virus infection, neurologic complications developed in 7 adults (median age 31 years). These complications were clinically diagnosed as confirmed encephalitis (4 patients), possible encephalitis (2 patients), and cerebellar ataxia (1 patient). Two of the patients died. Virus sequencing identified influenza virus B (Yam)-lineage clade 3, which is representative of the B/Phuket/3073/2013 strain, in 4 patients. None of the patients had been vaccinated against influenza. These results suggest that influenza B virus can cause a severe clinical course and should be considered as an etiologic factor for encephalitis.
我们对罗马尼亚一家三级医疗机构在2014 - 15年流感流行季节期间大量住院成人中与乙型流感病毒相关的神经学表现进行了特征描述。在32例实验室确诊为乙型流感病毒感染的患者中，7名成人（中位年龄31岁）出现了神经并发症。这些并发症临床诊断为确诊脑炎（4例患者）、可能脑炎（2例患者）和小脑共济失调（1例患者）。两名患者死亡。病毒测序在4例患者中鉴定出乙型流感病毒（山形）谱系3，它是B/普吉/3073/2013毒株的代表。所有患者均未接种流感疫苗。这些结果表明，乙型流感病毒可导致严重的临床病程，应被视为脑炎的病因之一。
