Heinemann Klaas, Barnett Clare, Reed Suzanne, Möhner Sabine, Do Minh Thai
ZEG - Berlin Center for Epidemiology and Health Research, Berlin, Germany.
ZEG - Berlin Center for Epidemiology and Health Research, Berlin, Germany.
Contraception. 2017 Jun;95(6):605-607. doi: 10.1016/j.contraception.2017.03.007. Epub 2017 Mar 16.
The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations.
We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definition for perforation.
Of the 61,448 women enrolled (70% levonorgestrel, 30% copper devices), we identified 58 complete perforations, 30 of which occurred in lactating women. Incidence per 1000 insertions was 4.5 (95% confidence interval [CI]: 3.0-6.4) for lactating and 0.6 (95% CI: 0.4-0.9) for nonlactating women. Time since delivery was also associated with perforation risk.
Lactation and delivery are independent cofactors for perforation. Results do not differ when restricting the definition of perforation.
本研究的目的是确定分娩和哺乳是否为宫内节育器完全穿孔的危险因素。
我们对欧洲宫内节育器主动监测研究数据集进行了重新分析，将子宫肌层完全穿透作为穿孔的定义。
在纳入的61448名女性中（70%使用左炔诺孕酮宫内节育器，30%使用铜宫内节育器），我们识别出58例完全穿孔，其中30例发生在哺乳期女性中。哺乳期女性每1000次放置的发生率为4.5（95%置信区间[CI]：3.0 - 6.4），非哺乳期女性为0.6（95%CI：0.4 - 0.9）。分娩后的时间也与穿孔风险相关。
哺乳和分娩是穿孔的独立协同因素。在限制穿孔定义时结果无差异。
