来自人体组织的树突状细胞表达免疫调节性维生素D3代谢产物二羟胆钙化醇的受体。
Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol.
作者信息
Brennan A, Katz D R, Nunn J D, Barker S, Hewison M, Fraher L J, O'Riordan J L
机构信息
Bland-Sutton Institute of Pathology, University College and Middlesex School of Medicine, London, U.K.
出版信息
Immunology. 1987 Aug;61(4):457-61.
Abstract
Dendritic cells have been isolated from human tonsillar tissue and shown to act as accessory cells in a mitogenic response. The dendritic cells will induced receptors for the active metabolite of vitamin D3, 1,25(OH)2D3, in the responder E+ T cells. The dendritic cells themselves constitutively express receptors for the metabolite, and this distinguishes them from other non-T cells in lymphomedullary tissue. Expression of the 1,25(OH)2D3 receptor may be a dendritic cell property that facilitates their accessory cell role within the tissue microenvironment.
摘要
树突状细胞已从人扁桃体组织中分离出来，并被证明在促有丝分裂反应中作为辅助细胞发挥作用。树突状细胞会在反应性E + T细胞中诱导维生素D3的活性代谢物1,25(OH)2D3的受体。树突状细胞本身组成性地表达该代谢物的受体，这使其与淋巴髓组织中的其他非T细胞区分开来。1,25(OH)2D3受体的表达可能是树突状细胞的一种特性，有助于它们在组织微环境中发挥辅助细胞的作用。
相似文献
1
2
Regulation of human tonsillar T-cell proliferation by the active metabolite of vitamin D3.维生素D3活性代谢产物对人扁桃体T细胞增殖的调节作用
Immunology. 1986 Dec;59(4):479-84.
3
Vitamin D affects proliferation of a murine T helper cell clone.
J Immunol. 1987 Mar 15;138(6):1680-6.
4
1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation.1,25-二羟基维生素D3抑制抗原诱导的T细胞活化。
J Immunol. 1984 Oct;133(4):1748-54.
5
1alpha,25-Dihydroxyvitamin D3 modulates CD38 expression on human lymphocytes.1α,25-二羟基维生素D3调节人淋巴细胞上CD38的表达。
J Immunol. 1996 Dec 1;157(11):4908-17.
6
1 alpha,25-Dihydroxyvitamin D3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production.人B淋巴细胞中1α,25-二羟维生素D3结合大分子：对免疫球蛋白产生的影响。
J Immunol. 1986 Apr 15;136(8):2734-40.
7
Defective binding and function of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with end-organ resistance to 1,25-dihydroxyvitamin D.1,25-二羟维生素D3受体在对1,25-二羟维生素D终末器官抵抗患者外周血单个核细胞中的结合及功能缺陷
J Clin Invest. 1985 Nov;76(5):2012-5. doi: 10.1172/JCI112201.
8
The role of vitamin D3 receptor mRNA in the proliferation of hepatocellular carcinoma.维生素D3受体mRNA在肝细胞癌增殖中的作用。
Hepatogastroenterology. 2000 Mar-Apr;47(32):468-72.
9
High performance liquid chromatography analysis of 1,25-dihydroxyvitamin D3 receptor in malignant cells. Correlation of effects on cell proliferation and receptor concentration.
Cancer Biochem Biophys. 1986 Jul;8(3):221-34.
10
Regulation of epidermal growth factor receptor levels by 1,25-dihydroxyvitamin D3 in human breast cancer cells.1,25-二羟基维生素D3对人乳腺癌细胞中表皮生长因子受体水平的调节
Cancer Res. 1988 May 15;48(10):2734-9.
引用本文的文献
1
The Role of Vitamin D and Vitamin D Receptor in Sepsis.维生素D及维生素D受体在脓毒症中的作用
Curr Issues Mol Biol. 2025 Jul 1;47(7):500. doi: 10.3390/cimb47070500.
2
Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.产前和产后维生素D状态与儿童早期过敏结局
Biomedicines. 2022 Apr 19;10(5):933. doi: 10.3390/biomedicines10050933.
3
Effects of Parenteral Vitamin D3 Supplementation on Hematological Parameters of Healthy Holstein Bulls.静脉注射维生素 D3 对健康荷斯坦公牛血液学参数的影响。
Arch Razi Inst. 2021 Nov 30;76(5):1509-1517. doi: 10.22092/ari.2020.352209.1552. eCollection 2021 Nov.
4
Novel insight into the role of the vitamin D receptor in the development and function of the immune system.维生素 D 受体在免疫系统发育和功能中的作用的新见解。
J Steroid Biochem Mol Biol. 2022 May;219:106084. doi: 10.1016/j.jsbmb.2022.106084. Epub 2022 Feb 22.
5
Autoimmune disease and interconnections with vitamin D.自身免疫性疾病及其与维生素D的关联。
Endocr Connect. 2022 Mar 31;11(3):e210554. doi: 10.1530/EC-21-0554.
6
The role of vitamin D in sarcoidosis.维生素D在结节病中的作用。
Fac Rev. 2020 Nov 18;9:14. doi: 10.12703/b/9-14. eCollection 2020.
7
Vitamin D Modulation of the Innate Immune Response to Paediatric Respiratory Pathogens Associated with Acute Lower Respiratory Infections.维生素 D 对与小儿下呼吸道感染相关的呼吸道病原体固有免疫反应的调节作用。
Nutrients. 2021 Jan 19;13(1):276. doi: 10.3390/nu13010276.
8
Vitamin D attenuates HMGB1-mediated neointimal hyperplasia after percutaneous coronary intervention in swine.维生素 D 可减轻猪经皮冠状动脉介入治疗后高迁移率族蛋白 B1 介导的新生内膜增生。
Mol Cell Biochem. 2020 Nov;474(1-2):219-228. doi: 10.1007/s11010-020-03847-y. Epub 2020 Aug 1.
9
The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial.维生素 D 补充对同卵双胞胎维生素 D 受体基因表达和身体成分的影响：随机对照试验。
Sci Rep. 2020 Jul 20;10(1):11943. doi: 10.1038/s41598-020-69128-2.
10
Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis.维生素 D 及其相关分子在与血栓形成发病机制相关途径中的新兴作用。
Biomolecules. 2019 Oct 24;9(11):649. doi: 10.3390/biom9110649.
本文引用的文献
1
Regulation of the immune response by prostaglandins.前列腺素对免疫反应的调节
Clin Immunol Immunopathol. 1980 Jan;15(1):106-22. doi: 10.1016/0090-1229(80)90024-0.
2
Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.树突状细胞在Ir基因控制下诱导T细胞对合成抗原的增殖。
J Exp Med. 1980 Dec 1;152(6):1817-22. doi: 10.1084/jem.152.6.1817.
3
Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite.一种维生素D代谢物对HL-60白血病细胞中myc基因表达的调控
Nature. 1983;306(5942):492-4. doi: 10.1038/306492a0.
4
Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas.小鼠脾脏树突状细胞将可溶性抗原呈递给抗原特异性T细胞杂交瘤。
J Exp Med. 1983 Nov 1;158(5):1745-50. doi: 10.1084/jem.158.5.1745.
5
Human dendritic cells. Enrichment and characterization from peripheral blood.人树突状细胞。从外周血中富集与鉴定。
J Exp Med. 1982 Apr 1;155(4):1172-87. doi: 10.1084/jem.155.4.1172.
6
Alloreactive cytotoxic T lymphocyte responses to H-2 products on purified accessory cells.对纯化辅助细胞上H-2产物的同种反应性细胞毒性T淋巴细胞反应。
Immunology. 1982 Mar;45(3):553-60.
7
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man.树突状细胞是小鼠和人类中胸腺依赖性抗体反应的关键辅助细胞。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):6041-5. doi: 10.1073/pnas.80.19.6041.
8
Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro.体外初次抗体应答过程中树突状细胞、辅助性T淋巴细胞和组织相容性B细胞的聚集
J Exp Med. 1984 Sep 1;160(3):858-76. doi: 10.1084/jem.160.3.858.
9
1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation.1,25-二羟基维生素D3抑制抗原诱导的T细胞活化。
J Immunol. 1984 Oct;133(4):1748-54.
10
Veiled (dendritic) cells in synovial fluid.滑液中的隐蔽（树突状）细胞。
Lancet. 1983 Feb 26;1(8322):472-3. doi: 10.1016/s0140-6736(83)91468-x.
Zotero 插件