小鼠脾脏树突状细胞将可溶性抗原呈递给抗原特异性T细胞杂交瘤。
Mouse spleen dendritic cells present soluble antigens to antigen-specific T cell hybridomas.
作者信息
Sunshine G H, Gold D P, Wortis H H, Marrack P, Kappler J W
出版信息
J Exp Med. 1983 Nov 1;158(5):1745-50. doi: 10.1084/jem.158.5.1745.
Abstract
In the presence of the soluble polypeptide antigens ovalbumin and keyhole limpet hemocyanin, purified mouse spleen dendritic cells induce the secretion of IL-2 by antigen-specific T cell hybridomas. This response is H-2 restricted and can be specifically inhibited by monoclonal anti-I-A. These data indicate that dendritic cells can present soluble antigen to H-2-compatible T cells.
摘要
在可溶性多肽抗原卵清蛋白和钥孔戚血蓝蛋白存在的情况下，纯化的小鼠脾脏树突状细胞可诱导抗原特异性T细胞杂交瘤分泌白细胞介素-2。这种反应受H-2限制，并且可被单克隆抗I-A特异性抑制。这些数据表明，树突状细胞能够将可溶性抗原呈递给H-2相容的T细胞。
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