Langmann Gabrielle A, Perera Subashan, Ferchak Mary A, Nace David A, Resnick Neil M, Greenspan Susan L
Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania.
J Am Geriatr Soc. 2017 Aug;65(8):1777-1783. doi: 10.1111/jgs.14876. Epub 2017 Mar 21.
To determine whether proinflammatory biomarkers are associated with frailty assessed according to functional status, mobility, mental health, and falls over 24 months.
Secondary analysis of a 2-year double-blind clinical trial for osteoporosis.
Nursing homes and assisted living facilities.
Women aged 65 and older with osteoporosis in long-term care (LTC) (N = 178).
Baseline serum concentrations of proinflammatory cytokines and soluble receptors (high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNFα) and its two receptors (TNFα-R1 and TNFα-R2), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL-10), functional status assessed according to activities of daily living, the Nursing Home Physical Performance Test, gait speed, cognitive status, mental health, and falls.
At baseline, older age was moderately associated with higher serum concentrations of hs-CRP (correlation coefficient (r) = 0.22), TNFα-R1 (r = 0.36), TNFα-R2 (r = 0.34), and IL-10 (r = 0.16) (all P < .05). Frail participants had significantly higher hs-CRP, TNFα-R1, TNFα-R2, IL-6, and IL-6-sR levels (all P < .05) than those nonfrail participants. Higher baseline hs-CRP and IL-6 levels were associated with worse physical performance and gait speed at 12 months independent of age, zoledronic acid use, and comorbidity (|r| = 0.25-0.30; all P < .05). Inflammatory markers were not significantly associated with incident falls.
Higher proinflammatory biomarker levels are associated with frailty and poorer function and mobility in older women residing in LTC facilities.
确定促炎生物标志物是否与根据功能状态、活动能力、心理健康以及24个月内跌倒情况评估的衰弱相关。
一项为期2年的骨质疏松症双盲临床试验的二次分析。
养老院和辅助生活设施。
长期护理（LTC）机构中65岁及以上患有骨质疏松症的女性（N = 178）。
促炎细胞因子和可溶性受体的基线血清浓度（高敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNFα）及其两种受体（TNFα-R1和TNFα-R2）、白细胞介素-6（IL-6）、可溶性IL-6受体（sIL-6R）、IL-10），根据日常生活活动、养老院身体性能测试、步速、认知状态、心理健康和跌倒情况评估的功能状态。
在基线时，年龄较大与hs-CRP（相关系数（r）= 0.22）、TNFα-R1（r = 0.36）、TNFα-R2（r = 0.34）和IL-10（r = 0.16）的血清浓度较高呈中度相关（所有P < 0.05）。衰弱参与者的hs-CRP、TNFα-R1、TNFα-R2、IL-6和IL-6-sR水平显著高于非衰弱参与者（所有P < 0.05）。较高的基线hs-CRP和IL-6水平与12个月时较差的身体性能和步速相关，与年龄、唑来膦酸使用情况和合并症无关（|r| = 0.25 - 0.30；所有P < 0.05）。炎症标志物与跌倒发生率无显著关联。
较高的促炎生物标志物水平与长期护理机构中老年女性衰弱以及较差的功能和活动能力相关。
