Batra Priya, Sharma Anil K
Department of Biotechnology, MMEC, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, 133207, India.
3 Biotech. 2013 Dec;3(6):439-459. doi: 10.1007/s13205-013-0117-5. Epub 2013 Feb 12.
Cancer is a major public health concern in both developed and developing countries. Several plant-derived anti-cancer agents including taxol, vinblastine, vincristine, the campothecin derivatives, topotecan, irinotecan and etoposide are in clinical use all over the world. Other promising anti-cancer agents include flavopiridol, roscovitine, combretastatin A-4, betulinic acid and silvestrol. From this list one can well imagine the predominance of polyphenols, flavonoids and their synthetic analogs in the treatment of ovarian, breast, cervical, pancreatic and prostate cancer. Flavonoids present in human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. A positive correlation between flavonoids-rich diet (from vegetables and fruits) and lower risk of colon, prostate and breast cancers lead to a question that whether flavonoids mediate the protective effects as chemopreventive agents or can interact with different genes and proteins to play role in chemotherapy. The current review emphasizes onto the therapeutic potential of flavonoids and their synthetic analogs as anti-cancer agents by providing new insights into the factors, regulation and molecular mechanisms along with their significant protein interactions.
癌症是发达国家和发展中国家主要的公共卫生问题。几种植物来源的抗癌药物，包括紫杉醇、长春碱、长春新碱、喜树碱衍生物、拓扑替康、伊立替康和依托泊苷，在世界各地都有临床应用。其他有前景的抗癌药物包括黄酮哌醇、罗斯考维汀、康普瑞他汀A - 4、桦木酸和白藜芦醇。从这份清单中可以很容易想象出多酚、黄酮类化合物及其合成类似物在治疗卵巢癌、乳腺癌、宫颈癌、胰腺癌和前列腺癌方面的主导地位。人类饮食中的黄酮类化合物包含许多具有广谱药理活性的多酚类次生代谢产物，包括它们作为抗癌药物的潜在作用。富含黄酮类化合物的饮食（来自蔬菜和水果）与较低的结肠癌、前列腺癌和乳腺癌风险之间的正相关关系引发了一个问题，即黄酮类化合物是作为化学预防剂介导保护作用，还是可以与不同的基因和蛋白质相互作用在化疗中发挥作用。本综述通过提供对相关因素、调控和分子机制以及它们重要的蛋白质相互作用的新见解，强调了黄酮类化合物及其合成类似物作为抗癌药物的治疗潜力。
