Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain.
Madrid Institute for Advanced Studies on Food (IMDEA-Food), Madrid, Spain.
Crit Rev Oncol Hematol. 2017 Apr;112:31-40. doi: 10.1016/j.critrevonc.2017.02.001. Epub 2017 Feb 13.
Lung cancer is currently one of the most serious health issues in developed and developing countries. There are multiple available treatment options; however survival still remains very poor. Despite metabolism alteration being one of the hallmarks described in human cancer, lipid metabolism disorders are less known. They are recently becoming more important in this setting and therefore achieving a deeper knowledge might be helpful to obtain new strategies to accurate diagnosis, estimate prognosis, and develop therapeutic agents based on bioactive compounds such as cerulenin, SCD1, ACLY inhibitors, statins, polyphenolic compounds, etc. The present paper reviews the basis of lipid metabolism in lung cancer and suggests potential biomarkers. Further investigation is crucial to improve our knowledge in this area.
肺癌是目前发达国家和发展中国家最严重的健康问题之一。有多种可用的治疗方法；然而，存活率仍然非常低。尽管代谢改变是人类癌症的特征之一，但脂质代谢紊乱知之甚少。在这种情况下，它们最近变得越来越重要，因此，深入了解这一问题可能有助于获得新的策略，以准确诊断、估计预后，并开发基于生物活性化合物的治疗剂，如苍术苷、SCD1、ACLY 抑制剂、他汀类药物、多酚化合物等。本文综述了肺癌中脂质代谢的基础，并提出了潜在的生物标志物。进一步的研究对于提高我们在这一领域的认识至关重要。
