人类遗传学与睡眠行为。
Human genetics and sleep behavior.
作者信息
Shi Guangsen, Wu David, Ptáček Louis J, Fu Ying-Hui
机构信息
Kavli Institute for Fundamental Neuroscience, Weill Institute of Neuroscience, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, United States; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, United States.
Kavli Institute for Fundamental Neuroscience, Weill Institute of Neuroscience, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, United States.
出版信息
Curr Opin Neurobiol. 2017 Jun;44:43-49. doi: 10.1016/j.conb.2017.02.015. Epub 2017 Mar 16.
Why we sleep remains one of the greatest mysteries in science. In the past few years, great advances have been made to better understand this phenomenon. Human genetics has contributed significantly to this movement, as many features of sleep have been found to be heritable. Discoveries about these genetic variations that affect human sleep will aid us in understanding the underlying mechanism of sleep. Here we summarize recent discoveries about the genetic variations affecting the timing of sleep, duration of sleep and EEG patterns. To conclude, we also discuss some of the sleep-related neurological disorders such as Autism Spectrum Disorder (ASD) and Alzheimer's Disease (AD) and the potential challenges and future directions of human genetics in sleep research.
为什么我们需要睡眠仍然是科学界最大的谜团之一。在过去几年里，为了更好地理解这一现象已经取得了巨大进展。人类遗传学对这一进展做出了重大贡献，因为人们发现睡眠的许多特征是可遗传的。关于这些影响人类睡眠的基因变异的发现将有助于我们理解睡眠的潜在机制。在这里，我们总结了关于影响睡眠时间、睡眠时长和脑电图模式的基因变异的最新发现。最后，我们还讨论了一些与睡眠相关的神经疾病，如自闭症谱系障碍（ASD）和阿尔茨海默病（AD），以及人类遗传学在睡眠研究中的潜在挑战和未来方向。
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