Department of Neurology, Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA.
Department of Neurology, Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA.
Curr Opin Neurobiol. 2021 Aug;69:19-24. doi: 10.1016/j.conb.2020.11.012. Epub 2020 Dec 25.
Sleep regulation has a strong genetic component. In this review, we highlight the recent advances in sleep genetics from knockout, point mutation, and GWAS studies. We overview specific genetic effects on REM versus NREM sleep as well as how the implicated genes fall in broad functional categories. Furthermore, we elucidate how genes affect different aspects of sleep including sleep duration, sleep consolidation, recovery sleep, and the circadian timing of sleep, demonstrating that genetic studies can be powerful in understanding how the body regulates sleep.
睡眠调节具有很强的遗传成分。在这篇综述中，我们强调了从基因敲除、点突变和 GWAS 研究中得出的睡眠遗传学的最新进展。我们概述了特定基因对 REM 与 NREM 睡眠的影响，以及所涉及的基因如何归入广泛的功能类别。此外，我们阐明了基因如何影响睡眠的不同方面，包括睡眠时间、睡眠巩固、恢复性睡眠和睡眠的昼夜节律时间，证明了遗传研究在理解身体如何调节睡眠方面具有强大的作用。
