Köbe Theresa, Witte A Veronica, Schnelle Ariane, Tesky Valentina A, Pantel Johannes, Schuchardt Jan-Philipp, Hahn Andreas, Bohlken Jens, Grittner Ulrike, Flöel Agnes
Department of Neurology, Charité - University Medicine BerlinBerlin, Germany; NeuroCure Cluster of Excellence, Charité - University Medicine BerlinBerlin, Germany.
Department of Neurology, Charité - University Medicine BerlinBerlin, Germany; NeuroCure Cluster of Excellence, Charité - University Medicine BerlinBerlin, Germany; Department of Neurology, Max Planck Institute of Human Cognitive and Brain SciencesLeipzig, Germany; SFB 1052 Obesity Mechanism Subproject A1, University of LeipzigLeipzig, Germany.
Front Neurosci. 2017 Mar 7;11:105. doi: 10.3389/fnins.2017.00105. eCollection 2017.
In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50-80 years) completed 26 weeks of resveratrol (200 mg/d; = 18) or placebo (1,015 mg/d olive oil; = 22) intake. Serum levels of glucose, glycated hemoglobin A1c and insulin were determined before and after intervention. Moreover, cerebral magnetic resonance imaging (MRI) (3T) ( = 14 vs. 16) was conducted to analyze hippocampus volume, microstructure and RSFC, and neuropsychological testing was conducted to assess learning and memory (primary endpoint) at both time points. In comparison to the control group, resveratrol supplementation resulted in lower glycated hemoglobin A1c concentration with a moderate effect size (ANOVA = 0.059, Cohen's = 0.66), higher RSFC between right anterior hippocampus and right angular cortex ( < 0.001), and led to a moderate preservation of left anterior hippocampus volume (ANOVA = 0.061, Cohen's = 0.68). No significant differences in memory performance emerged between groups. This proof-of-concept study indicates for the first-time that resveratrol intake may reduce glycated hemoglobin A1c, preserves hippocampus volume, and improves hippocampus RSFC in at-risk patients for dementia. Larger trials with longer intervention time should now determine if these benefits can be validated and extended to cognitive function.
在健康的老年人中，补充白藜芦醇已被证明可改善长期血糖控制、海马体的静息态功能连接（RSFC）和记忆功能。在此，我们旨在研究这些有益效果是否也适用于痴呆高危人群，即轻度认知障碍（MCI）患者。在一项随机、双盲干预研究中，40例特征明确的MCI患者（21名女性；年龄50 - 80岁）完成了26周的白藜芦醇（200毫克/天；n = 18）或安慰剂（1015毫克/天橄榄油；n = 22）摄入。在干预前后测定血糖、糖化血红蛋白A1c和胰岛素的血清水平。此外，进行了脑磁共振成像（MRI）（3T）（n = 14对16）以分析海马体体积、微观结构和RSFC，并在两个时间点进行神经心理学测试以评估学习和记忆（主要终点）。与对照组相比，补充白藜芦醇导致糖化血红蛋白A1c浓度降低，效应量中等（方差分析P = 0.059，科恩d = 0.66），右侧前海马体与右侧角回之间的RSFC增加（P < 0.001），并导致左侧前海马体体积中度保留（方差分析P = 0.061，科恩d = 0.68）。两组之间在记忆表现上没有显著差异。这项概念验证研究首次表明，摄入白藜芦醇可能降低糖化血红蛋白A1c，保留海马体体积，并改善痴呆高危患者的海马体RSFC。现在应该进行更长干预时间的更大规模试验，以确定这些益处是否可以得到验证并扩展到认知功能。
