Kamata K
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Jpn J Pharmacol. 1987 Dec;45(4):439-47. doi: 10.1254/jjp.45.439.
To elucidate the functional connections between dopaminergic, GABAergic and opioid peptidergic systems in rats, electrophysiological, behavioral, neurochemical and histological investigations have been undertaken, focusing on the changes in drug sensitivity in the central nervous system (CNS). Changes in sensitivity in the CNS can be induced by denervation, chronic administration of antagonists or agonists, and by the inhibition of the axoplasmic transport system. It is conceivable that the changes in sensitivity of the CNS to transmitters may be related to the etiology of mental illnesses such as schizophrenia and mania and may be related to the symptoms of Parkinson's disease. Investigation of changes in sensitivity of the CNS to transmitters or drugs may provide the key for elucidating the biological nature of mental illness.
为阐明大鼠中多巴胺能、γ-氨基丁酸能和阿片肽能系统之间的功能联系，已开展了电生理学、行为学、神经化学和组织学研究，重点关注中枢神经系统（CNS）中药物敏感性的变化。中枢神经系统敏感性的变化可由去神经支配、长期给予拮抗剂或激动剂以及抑制轴浆运输系统诱导产生。可以想象，中枢神经系统对递质敏感性的变化可能与精神疾病如精神分裂症和躁狂症的病因有关，也可能与帕金森病的症状有关。研究中枢神经系统对递质或药物敏感性的变化可能为阐明精神疾病的生物学本质提供关键线索。
