Moussa Tarek A A, Kadasa Naif M S, Al Zahrani Hassan S, Ahmed Sarah Abdallah, Feng Peiying, Gerrits van den Ende Albertus H G, Zhang Yu, Kano Rui, Li Fuqiu, Li Shanshan, Song Yang, Dong Bilin, Rossato Luana, Dolatabadi Somayeh, Hoog Sybren de
Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt.
Biological Sciences Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
J Med Microbiol. 2017 May;66(5):560-569. doi: 10.1099/jmm.0.000451. Epub 2017 May 22.
The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia.
Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. globosa was carried out on the basis of concatenated sequences of ITS, TEF3 and CAL. A haplotype network of CAL sequences of 281 Sporothrix isolates was analysed to determine the population structure of S. globosa.
Nearly all cases of sporotrichosis caused by S. globosa in Asia were human. In contrast to the remaining pathogenic Sporothrix species, feline transmission was exceptional; nearly all regional cat-associated cases were caused by Sporothrix schenckii. While the latter species was highly variable and showed recombination, S. globosa seemed to be a clonal offshoot, as was Sporothrix brasiliensis. The origin of the segregants was located in an area of high variability in S. schenckii with a relatively high frequency of Asian strains.
In Asia, S. globosa was the prevalent species. The low diversity of S. globosa suggested a recent divergence with a founder effect of low variability from the variable ancestral species, S. schenckii.
本研究旨在评估亚洲球形孢子丝菌的主要来源和流行病学模式，并推测其进化起源。
采用荟萃分析方法，回顾了2007年1月起亚洲孢子丝菌病的病例及病例系列文献。基于ITS、TEF3和CAL的串联序列对相关球形孢子丝菌进行系统发育分析。分析了281株孢子丝菌分离株CAL序列的单倍型网络，以确定球形孢子丝菌的种群结构。
亚洲几乎所有由球形孢子丝菌引起的孢子丝菌病病例均为人类。与其他致病性孢子丝菌不同，猫传播情况罕见；几乎所有与猫相关的区域病例均由申克孢子丝菌引起。虽然后者高度可变且显示出重组，但球形孢子丝菌似乎是一个克隆分支，巴西孢子丝菌也是如此。分离株的起源位于申克孢子丝菌高变区，亚洲菌株的频率相对较高。
在亚洲，球形孢子丝菌是优势种。球形孢子丝菌的低多样性表明其与可变祖先物种申克孢子丝菌近期发生了分化，且存在低变异性的奠基者效应。
