Park So-Yeon, Kim Jung-In, Joo Yoon Ha, Lee Jung Chan, Park Jong Min
Department of Radiation Oncology, Seoul National University Hospital, Seoul 03080, Republic of Korea. Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 03080, Republic of Korea. Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea. Center for Convergence Research on Robotics, Advanced Institutes of Convergence Technology, Suwon 16229, Republic of Korea.
Phys Med Biol. 2017 May 7;62(9):3735-3756. doi: 10.1088/1361-6560/aa6866. Epub 2017 Mar 22.
We propose bilateral total body irradiation (TBI) utilizing a 3D printer and a 3D optical scanner. We acquired surface information of an anthropomorphic phantom with the 3D scanner and fabricated the 3D compensator with the 3D printer, which could continuously compensate for the lateral missing tissue of an entire body from the beam's eye view. To test the system's performance, we measured doses with optically stimulated luminescent dosimeters (OSLDs) as well as EBT3 films with the anthropomorphic phantom during TBI without a compensator, conventional bilateral TBI, and TBI with the 3D compensator (3D TBI). The 3D TBI showed the most uniform dose delivery to the phantom. From the OSLD measurements of the 3D TBI, the deviations between the measured doses and the prescription dose ranged from -6.7% to 2.4% inside the phantom and from -2.3% to 0.6% on the phantom's surface. From the EBT3 film measurements, the prescription dose could be delivered to the entire body of the phantom within ±10% accuracy, except for the chest region, where tissue heterogeneity is extreme. The 3D TBI doses were much more uniform than those of the other irradiation techniques, especially in the anterior-to-posterior direction. The 3D TBI was advantageous, owing to its uniform dose delivery as well as its efficient treatment procedure.
我们提出利用3D打印机和3D光学扫描仪进行双侧全身照射（TBI）。我们用3D扫描仪获取了一个人体模型的表面信息，并用3D打印机制作了3D补偿器，该补偿器可以从射野视角连续补偿全身横向缺失的组织。为了测试该系统的性能，我们在无补偿器的TBI、传统双侧TBI以及使用3D补偿器的TBI（3D TBI）过程中，使用光激发发光剂量计（OSLD）以及EBT3胶片对人体模型进行剂量测量。3D TBI对模型的剂量分布最为均匀。从3D TBI的OSLD测量结果来看，模型内部测量剂量与处方剂量之间的偏差范围为-6.7%至2.4%，模型表面的偏差范围为-2.3%至0.6%。从EBT3胶片测量结果来看，除了组织异质性极高的胸部区域外，处方剂量可以在±10%的精度范围内输送到模型的全身。3D TBI的剂量比其他照射技术更为均匀，尤其是在前后方向上。3D TBI因其均匀的剂量输送以及高效的治疗过程而具有优势。
